Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260, USA.
J Org Chem. 2011 Aug 19;76(16):6860-5. doi: 10.1021/jo200947e. Epub 2011 Jul 26.
We previously reported a fluorescent chemodosimeter for ozone. The β-elimination step after the ozonolysis of the chemodosimeter was too slow to be practical for real-time monitoring of ozone. We examined primary, secondary, and tertiary amines at various pHs. It was found that pyrrolidine in pH 9 buffer could accelerate the elimination to generate a fluorescence signal. The elimination step is now sufficiently rapid to monitor ozone exposure in real time. We also discovered that azetidine was distinctly effective for the same elimination reaction in a pH 6 buffer.
我们之前报道了一种用于检测臭氧的荧光化学计量器。化学计量器在臭氧分解后的β消除步骤过于缓慢，无法实时监测臭氧。我们在不同 pH 值下检查了伯、仲、叔胺。结果发现，在 pH 9 缓冲液中的吡咯烷可以加速消除生成荧光信号。消除步骤现在足够快，可以实时监测臭氧暴露。我们还发现，在 pH 6 缓冲液中，氮杂环丁烷对于相同的消除反应也具有明显的效果。
