Cynamon H A, Andres J M, Iafrate R P
Department of Pediatrics, University of Florida, Gainesville.
Gastroenterology. 1990 Apr;98(4):1013-6. doi: 10.1016/0016-5085(90)90027-x.
Chronic cholestatic liver disease in children frequently results in severe intractable pruritus. Current forms of therapy, including cholestyramine, are usually ineffective. Therefore, a 6-wk, double-blind, crossover study was designed to test the ability of rifampin to relieve pruritus in children with chronic cholestasis. Rifampin proved effective in alleviating pruritus in all five children tested compared with a placebo-treated group. After the 6-wk study period, rifampin was continued for 6 mo, and its effectiveness was maintained. No complications resulted from rifampin use. This study and a similar study in older patients with primary biliary cirrhosis suggest that a highly effective form of therapy is available for treatment of severe pruritus in patients with chronic cholestasis. These patients must be carefully selected and frequently monitored.
儿童慢性胆汁淤积性肝病常导致严重的顽固性瘙痒。包括消胆胺在内的目前治疗方法通常无效。因此，设计了一项为期6周的双盲交叉研究，以测试利福平缓解慢性胆汁淤积患儿瘙痒的能力。与安慰剂治疗组相比，利福平在所有5名受试儿童中均被证明能有效减轻瘙痒。在为期6周的研究期后，利福平持续使用6个月，其有效性得以维持。使用利福平未产生并发症。这项研究以及一项针对原发性胆汁性肝硬化老年患者的类似研究表明，有一种高效的治疗方法可用于治疗慢性胆汁淤积患者的严重瘙痒。这些患者必须经过仔细挑选并经常监测。
