两种不同的1型人类免疫缺陷病毒毒株由另一个人携带多年后传播给了一个个体。
Transmission of two distinct HIV type 1 strains to an individual that were harbored for many years by another.
作者信息
van Werkhoven Maaike B, Baan Elly, Bakker Margreet, Jurriaans Suzanne, Paxton William A, Pollakis Georgios
机构信息
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center of the University of Amsterdam, The Netherlands.
出版信息
AIDS Res Hum Retroviruses. 2012 Feb;28(2):225-7. doi: 10.1089/aid.2011.0178. Epub 2011 Jul 26.
The concept of transmission bottlenecks in HIV-1 infection is well established. Coinfections and superinfections have been increasingly documented and provide a founding cause for the expansion of viral diversity through recombination. It is still relatively unclear how HIV-1 will propagate and evolve in individuals infected with more than one viral strain. Here we report on the parallel transmission of genetically distant viral strains cocirculating in one individual over many years to a single recipient.
HIV-1感染中传播瓶颈的概念已得到充分确立。合并感染和重复感染的记录越来越多，它们是通过重组扩大病毒多样性的一个重要原因。目前仍相对不清楚HIV-1在感染了不止一种病毒株的个体中会如何传播和进化。在此，我们报告了多年来在一个个体中共存的基因差异较大的病毒株并行传播给单个接受者的情况。
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