Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Transfusion. 2012 Jan;52(1):76-81. doi: 10.1111/j.1537-2995.2011.03262.x. Epub 2011 Jul 25.
We analyzed neonatal factors that could affect hematopoietic variables of cord blood (CB) donated from Korean neonates.
The numbers of total nucleated cells (TNCs), CD34+ cells, and CD34+ cells/TNCs of CB in neonates were compared according to sex, gestational age, birth weight, birth weight centile for gestational age, and ABO blood group.
With 11,098 CB units analyzed, blood group O CB showed an increased number of TNCs, CD34+ cells, and CD34+ cells/TNCs compared with other blood groups. Although TNC counts were lower in males, no difference in the number of CD34+ cells was demonstrated because the number of CD34+ cells/TNCs was higher in males. An increase in the gestational age resulted in an increase in the number of TNCs and decreases in the number of CD34+ cells and CD34+ cells/TNCs. The numbers of TNCs, CD34+ cells, and CD34+ cells/TNCs increased according to increased birth weight centile as well as birth weight.
CB with blood group O has unique hematologic variables in this large-scale analysis of Korean neonates, although the impact on the storage policies of CB banks or the clinical outcome of transplantation remains to be determined.
我们分析了影响韩国新生儿脐血（CB）造血变量的新生儿因素。
根据性别、胎龄、出生体重、出生体重百分位、ABO 血型比较了新生儿 CB 中的总核细胞（TNC）、CD34+细胞和 CD34+细胞/TNC 的数量。
在分析的 11098 个 CB 单位中，与其他血型相比，O 型血 CB 显示出更多的 TNC、CD34+细胞和 CD34+细胞/TNC。尽管男性的 TNC 计数较低，但由于男性的 CD34+细胞/TNC 数量较高，因此 CD34+细胞的数量没有差异。胎龄增加导致 TNC 数量增加，CD34+细胞和 CD34+细胞/TNC 数量减少。TNC、CD34+细胞和 CD34+细胞/TNC 的数量随着出生体重百分位和出生体重的增加而增加。
在对韩国新生儿的大规模分析中，O 型血 CB 具有独特的血液学变量，尽管这对 CB 银行的储存政策或移植的临床结果的影响仍有待确定。
