Matsumoto Harunobu, Takai Noriyuki, Nasu Kaei, Narahara Hisashi
Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University, Oita, Japan.
J Obstet Gynaecol Res. 2011 Nov;37(11):1739-43. doi: 10.1111/j.1447-0756.2011.01593.x. Epub 2011 Jul 25.
Primary small cell carcinoma of the endometrium is rare and has an extremely poor prognosis. This report describes two cases of small cell carcinoma of the endometrium diagnosed as stage III. Case 1 was diagnosed as stage IIIc. She underwent surgery and chemotherapy. For a locally recurrent tumor, she received radiotherapy. She has been well with no evidence of disease for 4 years. Case 2 was diagnosed as stage IIIa. She underwent surgery. The tumor recurred soon after the surgery, and she died 33 days after the surgery. In the literature, the median survival reported for patients with stage III and IV is only 5 months. Case 1 is the 4th case showing long-term survival with advanced-stage disease. The optimal treatment for this rare tumor has not been established. Considering its rarity and variability, it is difficult to establish an evidence-based therapeutic regimen.
原发性子宫内膜小细胞癌罕见，预后极差。本报告描述了两例被诊断为Ⅲ期的子宫内膜小细胞癌病例。病例1被诊断为Ⅲc期。她接受了手术和化疗。对于局部复发肿瘤，她接受了放疗。她情况良好，4年来无疾病证据。病例2被诊断为Ⅲa期。她接受了手术。肿瘤在术后不久复发，她在术后33天死亡。在文献中，Ⅲ期和Ⅳ期患者报告的中位生存期仅为5个月。病例1是第4例显示晚期疾病长期生存的病例。这种罕见肿瘤的最佳治疗方法尚未确立。考虑到其罕见性和变异性，难以建立基于证据的治疗方案。
