Brudie Lorna A, Khan Faizan, Radi Michael J, Ahmad Sarfraz
Florida Hospital Gynecologic Oncology, Florida Hospital Cancer Institute, Orlando, FL 32804, USA.
Department of Pathology, Florida Hospital Cancer Institute, Orlando, FL 32804, USA.
Gynecol Oncol Rep. 2016 Jul 25;17:79-82. doi: 10.1016/j.gore.2016.07.004. eCollection 2016 Aug.
Endometrial serous carcinomas are very clinically aggressive, which constitutes 40% of all deaths and recurrences associated with endometrial cancer. Small-cell carcinoma of the endometrium is relatively rare but aggressive, and often presents a component of endometrioid carcinoma, and is not generally associated with serous carcinoma. Herein, we report a case of 74-year-old African-American female, who presented with intermittent post-menopausal bleeding for > 1-month. She underwent robotic-assisted laparoscopic hysterectomy, bilateral salpingo-oophorectomy, sentinel lymph node mapping, and pelvic-and-aortic lymphadenectomy. Final pathology was consistent with serous carcinoma of the endometrium in combination with neuroendocrine small-cell carcinoma. This extremely rare combination of tumors presents a challenge for treatment. The mainstay of treatment seems to be surgery followed by chemotherapy ± radiation therapy. To our knowledge, it represents an under-reported area of gynecological medicine.
子宫内膜浆液性癌在临床上具有很强的侵袭性，占所有与子宫内膜癌相关的死亡和复发病例的40%。子宫内膜小细胞癌相对罕见但具有侵袭性，常呈现子宫内膜样癌成分，一般与浆液性癌无关。在此，我们报告一例74岁非裔美国女性病例，该患者绝经后出现间歇性阴道出血超过1个月。她接受了机器人辅助腹腔镜子宫切除术、双侧输卵管卵巢切除术、前哨淋巴结定位及盆腔和主动脉旁淋巴结清扫术。最终病理结果显示为子宫内膜浆液性癌合并神经内分泌小细胞癌。这种极其罕见的肿瘤组合给治疗带来了挑战。治疗的主要方法似乎是手术，随后进行化疗±放疗。据我们所知，这是妇科医学中一个报道不足的领域。
