Developmental Neurophysiology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Neuron. 2011 Jul 28;71(2):332-47. doi: 10.1016/j.neuron.2011.05.041.
The coactivation of prefrontal and hippocampal networks in oscillatory rhythms is critical for precise information flow in mnemonic and executive tasks, yet the mechanisms governing its development are still unknown. Here, we demonstrate that already in neonatal rats, patterns of discontinuous oscillatory activity precisely entrain the firing of prefrontal neurons and have distinct spatial and temporal organization over cingulate and prelimbic cortices. Moreover, we show that hippocampal theta bursts drive the generation of neonatal prefrontal oscillations by phase-locking the neuronal firing via axonal pathways. Consequently, functional impairment of the hippocampus reduces the prefrontal activity. With ongoing maturation continuous theta-gamma oscillations emerge and mutually entrain the prejuvenile prefrontal-hippocampal networks. Thus, theta-modulated communication within developing prefrontal-hippocampal networks may be relevant for circuitry refinement and maturation of functional units underlying information storage at adulthood.
前额叶和海马网络在振荡节律中的共同激活对于记忆和执行任务中精确的信息流至关重要，但控制其发展的机制尚不清楚。在这里，我们证明了在新生大鼠中，不连续的振荡活动模式精确地调节前额叶神经元的放电，并在扣带回和额前皮质上具有独特的空间和时间组织。此外，我们还表明，海马theta 爆发通过轴突途径锁定神经元放电来驱动新生儿前额叶振荡的产生。因此，海马功能障碍会降低前额叶活动。随着不断成熟，连续的 theta-γ 振荡出现，并使青少年前颞叶-海马网络相互同步。因此，发育中的前额叶-海马网络内的 theta 调制通讯可能与信息存储的功能单元的电路细化和成熟有关。
