Institute of Developmental Neurophysiology, Center for Molecular Neurobiology, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251, Hamburg, Germany.
Pflugers Arch. 2023 May;475(5):561-568. doi: 10.1007/s00424-023-02801-3. Epub 2023 Mar 3.
Rhythmic coordination in gamma oscillations provides temporal structure to neuronal activity. Gamma oscillations are commonly observed in the mammalian cerebral cortex, are altered early on in several neuropsychiatric disorders, and provide insights into the development of underlying cortical networks. However, a lack of knowledge on the developmental trajectory of gamma oscillations prevented the combination of findings from the immature and the adult brain. This review is intended to provide an overview on the development of cortical gamma oscillations, the maturation of the underlying network, and the implications for cortical function and dysfunction. The majority of information is drawn from work in rodents with particular emphasis on the prefrontal cortex, the developmental trajectory of gamma oscillations, and potential implications for neuropsychiatric disorders. Current evidence supports the idea that fast oscillations during development are indeed an immature form of adult gamma oscillations and can help us understand the pathology of neuropsychiatric disorders.
γ 节律的同步协调为神经元活动提供了时间结构。γ 节律在哺乳动物大脑皮层中普遍存在，在几种神经精神疾病中很早就发生改变，并为皮层网络的潜在发育提供了深入了解。然而，由于对 γ 节律发育轨迹缺乏了解，因此无法将不成熟和成年大脑的研究结果结合起来。本综述旨在概述皮层 γ 节律的发育、基础网络的成熟及其对皮层功能和功能障碍的影响。大部分信息来自啮齿动物的研究，特别强调前额叶皮层、γ 节律的发育轨迹以及对神经精神疾病的潜在影响。目前的证据支持这样一种观点，即发育过程中的快速振荡确实是成年 γ 节律的一种不成熟形式，可以帮助我们了解神经精神疾病的病理。
