Nat Genet. 2011 Jul 27;43(8):726-7. doi: 10.1038/ng.895.
Somatic mutations in mitochondrial DNA build up in aging tissues and are thought to contribute to physiological aging. Surprisingly, it is not known if these mutations occur early or late in life. A new study looks at mechanisms of accelerated mitochondrial aging in HIV-infected individuals treated with nucleoside analog anti-retroviral drugs and offers support for an early origin of mitochondrial DNA mutations.
线粒体 DNA 的体细胞突变在衰老组织中积累，被认为是导致生理衰老的原因之一。令人惊讶的是，目前尚不清楚这些突变是发生在生命早期还是晚期。一项新的研究着眼于接受核苷类似物抗逆转录病毒药物治疗的 HIV 感染者中线粒体加速衰老的机制，并为线粒体 DNA 突变的早期起源提供了支持。
