Ozoux J P, de Calan L, Perrier M, Berton C, Favre J P, Brizon J
Service de Chirurgie Digestive, Hôpital Bretonneau, Tours, France.
Int J Colorectal Dis. 1990 Feb;5(1):25-30. doi: 10.1007/BF00496146.
From January 1976 to June 1986, 154 patients (75 men and 79 women) who were 75 years of age or older were admitted for the surgical treatment of a colonic cancer. The mean age was 80.7 years. Patients were divided into two groups: 66 patients, between 75 and 80 years of age, were in Group I; 88 patients, 80 years of age and older, were in Group II. One hundred and forty-three patients (93%) were operated on and a resection was carried out in 125 patients (87%). The overall post-operative mortality rate was 12% (Group I: 5%; Group II: 17%; p less than 0.02). The actuarial survival rate of patients operated on was 32 +/- 8% at 3 years and 26 +/- 8% at 5 years (Group I: 37%; Group II: 17%). In both groups the survival rate was closely related to the extent of the disease according to Dukes classification. These results suggest that in the 75-80 year group age alone should no longer be considered a major risk factor for immediate surgical outcome. In patients aged 80 and older, the results are worse but it is not advanced age per se which influences mortality, rather the physiologic status of the patient.
1976年1月至1986年6月,154例75岁及以上的患者(75名男性和79名女性)因结肠癌接受手术治疗。平均年龄为80.7岁。患者分为两组:66例年龄在75至80岁之间的患者为第一组;88例80岁及以上的患者为第二组。143例患者(93%)接受了手术,125例患者(87%)进行了切除。总体术后死亡率为12%(第一组:5%;第二组:17%;p<0.02)。接受手术患者的3年精算生存率为32±8%,5年为26±8%(第一组:37%;第二组:17%)。根据Dukes分类,两组的生存率均与疾病范围密切相关。这些结果表明,在75至80岁组中,不应再将年龄单独视为影响即刻手术结果的主要危险因素。在80岁及以上的患者中,结果较差,但影响死亡率的并非高龄本身,而是患者的生理状态。