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双胞胎中的川崎病。

Kawasaki disease in monozygotic twins.

机构信息

Department of Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, CA, USA.

出版信息

Pediatr Infect Dis J. 2011 Dec;30(12):1114-6. doi: 10.1097/INF.0b013e31822ac4ff.

DOI:10.1097/INF.0b013e31822ac4ff
PMID:21796015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3222730/
Abstract

Multiple lines of evidence suggest that susceptibility to Kawasaki disease (KD) is influenced by host genetics. Subclinical coronary artery vasculitis may be present in monozygotic twins who are discordant for clinical signs of KD. Health care providers should consider laboratory testing and echocardiography in both monozygotic twins when only one twin presents with clinical KD.

摘要

多项证据表明,川崎病(KD)的易感性受宿主遗传因素的影响。虽然双胞胎的临床症状不一致,但同卵双胞胎可能存在无症状性冠状动脉血管炎。当只有一个双胞胎出现临床 KD 时,医疗保健提供者应考虑对两个双胞胎都进行实验室检查和超声心动图检查。

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本文引用的文献

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Increased incidence and severity of Kawasaki disease among Filipino-Americans in San Diego county.圣地亚哥县菲律宾裔美国人川崎病发病率和严重程度增加。
Pediatr Infect Dis J. 2011 Oct;30(10):909-11. doi: 10.1097/INF.0b013e31821e52c6.
2
Epigenetic alterations in autoimmune rheumatic diseases.自身免疫性风湿病中的表观遗传学改变。
Nat Rev Rheumatol. 2011 May;7(5):263-71. doi: 10.1038/nrrheum.2011.16. Epub 2011 Feb 22.
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Racial/ethnic differences in the incidence of Kawasaki syndrome among children in Hawaii.夏威夷儿童川崎病发病率的种族/民族差异。
Hawaii Med J. 2010 Aug;69(8):194-7.
4
Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey.日本川崎病的流行病学特征:2007-2008 年全国调查结果。
J Epidemiol. 2010;20(4):302-7. doi: 10.2188/jea.je20090180. Epub 2010 Jun 5.
5
Molecular genetics of Kawasaki disease.川崎病的分子遗传学。
Pediatr Res. 2009 May;65(5 Pt 2):46R-54R. doi: 10.1203/PDR.0b013e31819dba60.
6
A genomewide linkage analysis of Kawasaki disease: evidence for linkage to chromosome 12.川崎病的全基因组连锁分析:与12号染色体连锁的证据
J Hum Genet. 2007;52(2):179-190. doi: 10.1007/s10038-006-0092-3. Epub 2006 Dec 8.
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