Department of Orthopaedic Surgery, Stanford Medicine Outpatient Center, 450 Broadway Street, Mailcode 6324, Redwood City, CA 94063, USA.
Clin Orthop Relat Res. 2012 Feb;470(2):490-6. doi: 10.1007/s11999-011-1967-y.
Defining the epidemiology of adverse events after THA will aid in the development of strategies to enhance perioperative care.
QUESTIONS/PURPOSES: We identified (1) risk factors for adverse events in Medicare beneficiaries while hospitalized after THA and (2) trends in the rates of adverse events.
Data were abstracted from medical records of 1809 Medicare beneficiaries who underwent THA from 2002 to 2007. We used the hierarchical generalized linear modeling approach to assess the odds of change in adverse events over time, the association of adverse events with outcomes, and the relationship of adverse events with patient characteristics by modeling the log-odds of adverse events as a function of demographic and clinical variables adjusted for year variable.
The overall rate of adverse events was 5.8%; the 30-day mortality rate was 1.00%. Increased age, obesity, and year of procedure were risk factors for experiencing any adverse event. Annual rates of adverse events from 2002 to 2007 were 9.1%, 8.2%, 4.9%, 4.1%, 3.5%, and 3.0%, respectively. Experiencing any adverse event was associated with an increased length of stay and an increased chance of readmission but not with an increased chance of mortality. The annual rate of all adverse events decreased from 2002-2004 to 2005-2007 (odds ratio = 0.83; 95% confidence interval, 0.74-0.92).
Older and obese patients should be counseled regarding their increased risk for the development of adverse events after THA. The cause of the decline in the rate of adverse events between two time periods is unclear and warrants further investigation to confirm and identify the cause.
定义全髋关节置换术后不良事件的流行病学情况将有助于制定增强围手术期护理的策略。
问题/目的:我们确定了(1)医疗保险受益人的髋关节置换术后住院期间不良事件的危险因素和(2)不良事件发生率的趋势。
从 2002 年至 2007 年期间接受髋关节置换术的 1809 名医疗保险受益人的病历中提取数据。我们使用层次广义线性模型方法来评估随时间变化的不良事件发生率变化的可能性、不良事件与结局的关联以及不良事件与患者特征的关系,方法是将不良事件的对数几率建模为调整年份变量的人口统计学和临床变量的函数。
不良事件的总体发生率为 5.8%;30 天死亡率为 1.00%。年龄增长、肥胖和手术年份是发生任何不良事件的危险因素。2002 年至 2007 年不良事件的年发生率分别为 9.1%、8.2%、4.9%、4.1%、3.5%和 3.0%。经历任何不良事件与住院时间延长和再入院机会增加相关,但与死亡率增加无关。所有不良事件的年发生率从 2002-2004 年降至 2005-2007 年(比值比=0.83;95%置信区间,0.74-0.92)。
对于髋关节置换术后发生不良事件风险增加的老年和肥胖患者,应进行咨询。两个时间段之间不良事件发生率下降的原因尚不清楚,需要进一步调查以确认和确定原因。