Chand N, Eyre P
Eur J Pharmacol. 1977 Oct 1;45(3):213-20. doi: 10.1016/0014-2999(77)90001-2.
Histamine, 2-methylhistamine (2-MeH: a relatively specific H1 receptor agonist), 5-HT, carbachol, bradykinin (BK) and PGF2alpha contract isolated cat pulmonary vein, artery and hepatic vein. PGE1, PGF2alpha and 4-methylhistamine (4-MeH: a relatively specific H2-receptor agonist) contract pulmonary arterial strips but further increase in the dose of PGE1 produces relaxation. Isoproterenol relaxes partially contracted blood vessels at low doses, but contracts at high doses. Cat trachea contracts to 5-HT, acetylcholine and carbachol but is insensitive to histamine, its analogues, BK and PGF2alpha. However, partially contracted trachea relaxes to histamine, 4-MeH, 2-MeH, isoprenaline, BK, PGE1, E2 and F2alpha. PGF2alpha and SRS-A contract cat bronchus. Isoprenaline, PGE1 and E2 relax cat bronchus contracted to carbachol, 5-HT, PGF2alpha, SRS-A and antigen. The in vitro anaphylactic contraction (Schultz-Dale reaction) of isolated pulmonary and hepatic veins, bronchus and trachea from horse plasma sensitized cat suggested the involvement of lung and liver in anaphylaxis of the cat.
组胺、2-甲基组胺（2-MeH：一种相对特异的H1受体激动剂）、5-羟色胺、卡巴胆碱、缓激肽（BK）和前列腺素F2α可使分离的猫肺静脉、动脉和肝静脉收缩。前列腺素E1、前列腺素F2α和4-甲基组胺（4-MeH：一种相对特异的H2受体激动剂）可使肺动脉条收缩，但前列腺素E1剂量进一步增加则产生舒张作用。异丙肾上腺素在低剂量时可使部分收缩的血管舒张，但在高剂量时则使其收缩。猫气管对5-羟色胺、乙酰胆碱和卡巴胆碱产生收缩反应，但对组胺及其类似物、BK和前列腺素F2α不敏感。然而，部分收缩的气管对组胺、4-MeH、2-MeH、异丙肾上腺素、BK、前列腺素E1、E2和F2α产生舒张反应。前列腺素F2α和慢反应物质-A可使猫支气管收缩。异丙肾上腺素、前列腺素E1和E2可使因卡巴胆碱、5-羟色胺、前列腺素F2α、慢反应物质-A和抗原而收缩的猫支气管舒张。从经马血浆致敏的猫分离出的肺静脉、肝静脉、支气管和气管的体外过敏收缩（舒尔茨-戴尔反应）提示肺和肝参与了猫的过敏反应。
