Chand N, Eyre P
J Pharm Pharmacol. 1978 Jul;30(7):432-5. doi: 10.1111/j.2042-7158.1978.tb13280.x.
Isolated chicken bronchus contracts to carbachol, PGF2alpha, histamine, 5-HT, bradykinin and phenylephrine. The bronchial strips from the horse plasma sensitized domestic fowl contracted to specific sensitizing antigen in vitro (Schultz-Dale anaphylactic reaction) and were 5 to 10 fold more reactive to PGF2alpha, histamine and 5-HT compared with the bronchi from normal chickens. Second antigen challenge was inactive or produced a weak response (desensitization). Allowing the bronchi to rest for 1 h resulted in partial recovery of anaphylactic response. Bronchi which had partially contracted submaximally to carbachol, antigen or PGF2alpha, relaxed to isoprenaline, adrenaline and PGE1 and E2.
分离出的鸡支气管对卡巴胆碱、前列腺素F2α、组胺、5-羟色胺、缓激肽和去氧肾上腺素产生收缩反应。来自马血浆致敏家禽的支气管条在体外对特定致敏抗原产生收缩反应（舒尔茨-戴尔过敏反应），与正常鸡的支气管相比，对前列腺素F2α、组胺和5-羟色胺的反应性高5至10倍。再次用抗原攻击则无活性或产生微弱反应（脱敏）。让支气管休息1小时会使过敏反应部分恢复。已对卡巴胆碱、抗原或前列腺素F2α产生部分亚最大收缩的支气管，对异丙肾上腺素、肾上腺素以及前列腺素E1和E2产生舒张反应。
