Laboratorio di Microbiologia e Virologia, Università "Vita-Salute" San Raffaele, Milano, Italy.
Antiviral Res. 2011 Oct;92(1):15-26. doi: 10.1016/j.antiviral.2011.07.013. Epub 2011 Jul 21.
The role of humoral response in the effective control of infection by influenza viruses is well known, but the protection is usually limited to the infecting or vaccinating isolate and to few related strains. Recent studies have evidenced the existence of B-cell epitopes broadly conserved among different influenza subtypes recognized by monoclonal antibodies endowed with unprecedented broad activity. In this review, all major monoclonal antibodies directed against different influenza virus proteins are reported and their potential in the design of new anti-influenza prophylactic or therapeutic strategies is discussed.
体液免疫反应在有效控制流感病毒感染方面的作用是众所周知的，但这种保护通常仅限于感染或接种的分离株和少数相关菌株。最近的研究表明，存在广泛存在于不同流感亚型中的 B 细胞表位，这些表位被具有前所未有的广泛活性的单克隆抗体所识别。在这篇综述中，报道了所有针对不同流感病毒蛋白的主要单克隆抗体，并讨论了它们在设计新的抗流感预防性或治疗性策略中的潜力。
