INSERM U, Hopital Paul Brousse, Batiment Lavoisier, Villejuif, France.
EMBO Rep. 2011 Sep 1;12(9):901-10. doi: 10.1038/embor.2011.157.
Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins-such as mitochondrial DNA and formyl peptides-can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling.
线粒体是参与宿主细胞代谢过程和程序性细胞死亡控制的细胞细胞器。MAVS-一种 RIGI 样受体信号的关键接头蛋白-作为一种定位于线粒体的蛋白质的鉴定，首次突出了线粒体与先天免疫信号之间的直接联系。最近，其他先天免疫分子，如 NLRX1、TRAF6、NLRP3 和 IRGM，已被证明与线粒体具有功能相关性。此外，受损线粒体可释放线粒体警报素，如线粒体 DNA 和甲酰肽，从而引发炎症。因此，线粒体成为先天免疫信号的一个基本枢纽。
