Shevkani Manoj, Kavina B, Kumar Pradeep, Purohit H, Nihalani U, Shah Asha
Associate Consultant, Infectious Disease & Tropical Medicine Clinic, and Ex. Regional Co-ordinator - CST (NACO), Ahmedabad.
Indian J Sex Transm Dis AIDS. 2011 Jan;32(1):9-13. doi: 10.4103/0253-7184.81247.
Average risk of acquiring HIV infection after a percutaneous exposure to HIV infected blood is 0.3%. Post exposure prophylaxis (PEP) for HIV refers to a set of comprehensive services to prevent HIV infection in exposed individuals where the exposure can be occupational/ non occupational and a provision of short term (28 days) antiretroviral drugs are given depending on the risk assessment. It also includes counselling and relevant laboratory investigations after taking informed consent of the exposed person and source. PEP inhibits the replication of the initial inoculum of virus and thereby prevents establishment of chronic HIV infection, and is best effective when initiated within 2 hours but certainly within 72 hours. Present communication deals with the registry of 278 cases of PEP from Gujarat in terms of various determinants, their status and the outcome in terms of HIV sero positivity.
经皮暴露于感染艾滋病毒的血液后感染艾滋病毒的平均风险为0.3%。艾滋病毒暴露后预防（PEP）是指为预防暴露个体感染艾滋病毒而提供的一套综合服务，暴露情况可以是职业性的/非职业性的，并且根据风险评估提供短期（28天）抗逆转录病毒药物。它还包括在获得暴露者和源的知情同意后进行咨询和相关实验室检查。PEP可抑制初始接种病毒的复制，从而防止慢性艾滋病毒感染的建立，在2小时内启动但肯定在72小时内启动时效果最佳。本通讯涉及古吉拉特邦278例PEP病例的登记情况，包括各种决定因素、其状况以及艾滋病毒血清阳性结果。
