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白术根茎精油的抗氧化能力。

Anti-Oxidative Abilities of Essential Oils from Atractylodes ovata Rhizome.

机构信息

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.

出版信息

Evid Based Complement Alternat Med. 2011;2011:204892. doi: 10.1093/ecam/neq006. Epub 2011 Jun 8.

DOI:10.1093/ecam/neq006
PMID:21799672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3135905/
Abstract

The rhizome of Atractylodes ovata De Candolle is rich in essential oils, which are usually removed by processing. In this study, anti-oxidative abilities of essential oils and aqueous extracts of A. ovata rhizome were explored, and the influence of processing on the anti-oxidative abilities was examined. Essential oils and aqueous extracts of A. ovata were extracted by boiling water and steam distillation, respectively. Quality of these two A. ovata samples was controlled by HPLC and GC-MS system, and anti-oxidative abilities were then evaluated. Results showed that surface color of A. ovata turned to brown and chemical components were changed by processing. Contents of both atractylon and atractylenolide II decreased in the essential oils, but only the contents of atractylon decreased by processing. Atractylenolide III increased in both A. ovata samples. However, A. ovata essential oils displayed stronger anti-oxidative abilities than aqueous extracts in DPPH-scavenging, TBH-induced lipid peroxidation and catalase activity assays. Moreover, the bioactivity of essential oils from raw A. ovata was stronger than oils from processed A. ovata. On the other hand, cytotoxicity of A. ovata essential oils was stronger than that of aqueous extracts, and was more sensitive on H9C2 cell than NIH-3T3 and WI-38 cells. In contrast, stir-frying processing method increased cytotoxicity of essential oils, but the cytotoxicity was ameliorated when processed with assistant substances. The results suggested that phytochemical components and bioactivity of A. ovata were changed after processing and the essential oils from raw A. ovata showed better anti-oxidative and fewer cytotoxicity effects.

摘要

白术根茎富含挥发油，通常在加工过程中去除。本研究探索了白术根茎挥发油和水提物的抗氧化能力，并考察了加工对其抗氧化能力的影响。采用水煮和水蒸气蒸馏法分别提取白术根茎的挥发油和水提物。采用 HPLC 和 GC-MS 系统控制这两种白术样品的质量，然后评价其抗氧化能力。结果表明，加工导致白术颜色变褐，化学成分发生变化。挥发油中的苍术酮和苍术醇含量降低，但仅加工导致苍术酮含量降低。两种白术样品中都有苍术三醇增加。然而，在 DPPH 清除、TBH 诱导的脂质过氧化和过氧化氢酶活性测定中，白术挥发油的抗氧化能力强于水提物。此外，生白术挥发油的生物活性强于炮制白术的挥发油。另一方面，白术挥发油的细胞毒性强于水提物，对 H9C2 细胞的敏感性高于 NIH-3T3 和 WI-38 细胞。相比之下，炒制加工方法增加了挥发油的细胞毒性，但辅助物质处理后可减轻其毒性。结果表明，白术在加工后其化学成分和生物活性发生了变化，生白术的挥发油具有更好的抗氧化和较少的细胞毒性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/89ee65d2bf3f/ECAM2011-204892.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/e6eb63f8a293/ECAM2011-204892.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/f44864aedb38/ECAM2011-204892.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/80892e9b3ae5/ECAM2011-204892.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/820c0a780aa7/ECAM2011-204892.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/100e1680d04f/ECAM2011-204892.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/89ee65d2bf3f/ECAM2011-204892.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/e6eb63f8a293/ECAM2011-204892.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/f44864aedb38/ECAM2011-204892.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/80892e9b3ae5/ECAM2011-204892.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/820c0a780aa7/ECAM2011-204892.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/100e1680d04f/ECAM2011-204892.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cb3/3135905/89ee65d2bf3f/ECAM2011-204892.006.jpg

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