Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho 2-chome, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.
Inflammation. 2012 Apr;35(2):713-22. doi: 10.1007/s10753-011-9364-y.
We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m(3) of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.
我们评估了氡吸入是否抑制了小鼠的角叉菜胶诱导的炎症。将角叉菜胶（1%v/v）皮下注射到已经或尚未吸入约 2000 Bq/m(3)氡 24 小时的小鼠的爪子中。氡吸入显著增加了小鼠爪子中超氧化物歧化酶（SOD）和过氧化氢酶的活性，并显著降低了脂质过氧化物的水平，表明氡吸入激活了抗氧化功能。角叉菜胶给药引起爪肿胀，并显著增加了血清中的肿瘤坏死因子-α（TNF-α）和一氧化氮。然而，氡吸入显著减轻了角叉菜胶诱导的爪肿胀。与假处理组小鼠相比，氡处理组小鼠的血清 TNF-α 水平较低。此外，氡处理组小鼠爪子中的 SOD 和过氧化氢酶活性也显著高于假处理组小鼠。这些发现表明，氡吸入具有抗炎作用，并抑制了角叉菜胶诱导的炎症性爪肿胀。
