Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.
J Dermatolog Treat. 2012 Dec;23(6):431-6. doi: 10.3109/09546634.2011.590790. Epub 2011 Jul 31.
Café au lait macules (CALMs) are a benign epidermal hyperpigmentation disorder. Although CALMs have been removed successfully with lasers, there have been few investigations on the use of the Q-switched 755-nm alexandrite laser.
To evaluate the efficacy and safety of the Q-switched 755-nm alexandrite laser for the treatment of CALMs in Chinese patients.
In this retrospective study, data of CALMs patients (n = 48) treated with a Q-switched 755-nm alexandrite laser were collected. Patients received an average of 3.2 treatments. Clinical responses were assessed by three blinded investigators. Adverse effects and recurrence rates were also evaluated. The mean follow-up time was 16.1 months.
Good to excellent responses were achieved in 26 patients (54.1%) and poor responses in 8 patients (16.7%). Recurrence was noted in five patients (10.4%) and transient hypopigmentation was observed in one patient. Efficacy was significantly greater in males than in females while patient age and lesional area did not show significant correlation with efficacy.
The Q-switched 755-nm alexandrite laser shows relatively high efficacy in removing CALMs and the recurrence rate is low. Males respond might more favorably than females.
牛奶咖啡斑（CALMs）是一种良性的表皮色素沉着障碍。尽管 CALMs 已经成功地通过激光去除，但对于 Q-开关 755nm 翠绿宝石激光的应用研究甚少。
评估 Q-开关 755nm 翠绿宝石激光治疗中国患者 CALMs 的疗效和安全性。
在这项回顾性研究中，收集了 48 例接受 Q-开关 755nm 翠绿宝石激光治疗的 CALMs 患者的数据。患者平均接受了 3.2 次治疗。由三位盲法研究者评估临床反应。还评估了不良反应和复发率。平均随访时间为 16.1 个月。
26 例（54.1%）患者获得良好至极好的反应，8 例（16.7%）患者反应较差。5 例（10.4%）患者复发，1 例患者出现短暂性色素减退。男性的疗效明显优于女性，而患者年龄和病变面积与疗效无显著相关性。
Q-开关 755nm 翠绿宝石激光去除 CALMs 的疗效较高，复发率较低。男性的反应可能比女性更有利。
