Department of Medicine and Therapeutics, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
Br J Nutr. 2012 Apr;107(7):1017-27. doi: 10.1017/S0007114511003795. Epub 2011 Aug 1.
Previous studies have suggested that Lingzhi (Ganoderma lucidum) has antioxidant effects and possibly beneficial effects on blood pressure, plasma lipids and glucose, but these have not been confirmed in subjects with mild hypertension or hyperlipidaemia. The objective of the present study was to assess the cardiovascular, metabolic, antioxidant and immunomodulatory responses to therapy with Lingzhi in patients with borderline elevations of blood pressure and/or cholesterol in a controlled cross-over trial. A total of twenty-six patients received 1·44 g Lingzhi daily or matching placebo for 12 weeks in a randomised, double-blind, cross-over study with placebo-controlled run-in and cross-over periods. Body weight, blood pressure, metabolic parameters, urine catecholamines and cortisol, antioxidant status and lymphocyte subsets were measured after each period. Lingzhi was well tolerated and data from twenty-three evaluable subjects showed no changes in BMI or blood pressure when treated with Lingzhi or placebo. Plasma insulin and homeostasis model assessment-insulin resistance were lower after treatment with Lingzhi than after placebo. TAG decreased and HDL-cholesterol increased with Lingzhi but not with placebo in the first treatment period, but significant carry-over effects prevented complete analysis of these parameters. Urine catecholamines and cortisol, plasma antioxidant status and blood lymphocyte subsets showed no significant differences across treatments. Results indicate that Lingzhi might have mild antidiabetic effects and potentially improve the dyslipidaemia of diabetes, as shown previously in some animal studies. Further studies are desirable in patients with hyperglycaemia.
先前的研究表明，灵芝（Ganoderma lucidum）具有抗氧化作用，并且可能对血压、血浆脂质和葡萄糖有益，但这些在轻度高血压或高脂血症患者中尚未得到证实。本研究的目的是在一项对照交叉试验中评估灵芝治疗对血压和/或胆固醇轻度升高患者的心血管、代谢、抗氧化和免疫调节反应。总共 26 名患者接受了 1.44 克灵芝或匹配的安慰剂，每天一次，持续 12 周，采用随机、双盲、交叉试验，有安慰剂对照的导入期和交叉期。在每个时期后测量体重、血压、代谢参数、尿儿茶酚胺和皮质醇、抗氧化状态和淋巴细胞亚群。灵芝耐受良好，23 名可评估受试者的数据显示，服用灵芝或安慰剂后 BMI 或血压均无变化。与安慰剂相比，服用灵芝后血浆胰岛素和稳态模型评估胰岛素抵抗降低。在第一个治疗期，灵芝可降低 TAG 和升高 HDL-胆固醇，但安慰剂无此作用，这表明存在显著的交叉作用，无法对这些参数进行完全分析。尿儿茶酚胺和皮质醇、血浆抗氧化状态和血液淋巴细胞亚群在不同治疗方法之间无显著差异。结果表明，灵芝可能具有轻度抗糖尿病作用，并可能改善糖尿病的血脂异常，这在以前的一些动物研究中已经得到证实。在高血糖患者中需要进一步研究。
