Karchev T, Kabakchiev P
Vestn Otorinolaringol. 1990 Jan-Feb(1):31-8.
In 1870, F. Hebra described a slowly progressing granulomatous disease of the nasal mucous membrane he called rhinoscleroma. Later, N. M. Volkovich and A. Frisch isolated from patients suffering from this disease a microorganism they termed Klebsiella rhinoscleromatis. In 1932, S. Belinov proposed to name the disease Scleroma respiratorium because the pathological process developing in rhinosclerosis may involve not only upper but also lower airways. In 1961, T. Steffen and J. Smith demonstrated that Klebsiella rhinoscleromatis conformed to Koch's postulates and was an etiological factor of inflammatory changes typical of scleroma. This paper presents results of ultrastructural examinations of Klebsiella rhinoscleromatis isolated from two patients with Scleroma respiratorium. It was shown that as the degenerative process developed, the amount of electron-dense material around the bacterial cell wall decreased progressively and only fragments of the cellular membrane remained.
1870年，F. 赫布拉描述了一种他称为鼻硬结病的鼻腔黏膜缓慢进展的肉芽肿性疾病。后来，N. M. 沃尔科维奇和A. 弗里施从患有这种疾病的患者身上分离出一种微生物，他们将其命名为鼻硬结克雷伯菌。1932年，S. 别利诺夫提议将该疾病命名为呼吸道硬结病，因为鼻硬结病中发生的病理过程不仅可能累及上呼吸道，还可能累及下呼吸道。1961年，T. 斯特芬和J. 史密斯证明鼻硬结克雷伯菌符合科赫法则，是硬结病典型炎症变化的病因。本文介绍了从两名呼吸道硬结病患者身上分离出的鼻硬结克雷伯菌的超微结构检查结果。结果表明，随着退行性过程的发展，细菌细胞壁周围电子致密物质的数量逐渐减少，仅留下细胞膜碎片。
