Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10, Rm. 5D39, 10 Center Drive, MSC 1402, Bethesda, MD, USA.
Prog Neurobiol. 2011 Dec;95(4):505-9. doi: 10.1016/j.pneurobio.2011.07.005. Epub 2011 Jul 23.
This commentary provides a brief introduction to the various uses that functional neuroimaging biomarkers can play in detecting, diagnosing, assessing treatment response and investigating neurodegenerative disorders. It then goes on to explain why the emphasis of much recent work has shifted to network-based biomarkers, as opposed to those that examine individual brain regions. A number of examples are referenced that illustrate the points made.
这篇述评简要介绍了功能神经影像学生物标志物在检测、诊断、评估治疗反应和研究神经退行性疾病方面的各种用途。接着，它解释了为什么最近的许多研究工作重点转向基于网络的生物标志物，而不是那些检查单个脑区的生物标志物。文中引用了一些例子来说明所提出的观点。
