CNRS UMR 7179, MNHN, Brunoy, France.
Ageing Res Rev. 2012 Jan;11(1):150-62. doi: 10.1016/j.arr.2011.07.001. Epub 2011 Jul 19.
The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of ageing. Results from studies of both healthy and pathological ageing research on the grey mouse lemur demonstrated that this animal is a unique model to study age-dependent changes in endocrine systems, biological rhythms, thermoregulation, sensorial, cerebral and cognitive functions.
使用非人类灵长类动物模型对于理解衰老过程和评估针对与年龄相关疾病的新疗法是必需的。本文总结了灰色小鼠猴 Microcebus murinus 的所有贡献，这是一种小型夜间灵长类动物，有助于理解衰老机制。对灰色小鼠猴进行的健康和病理性衰老研究的结果表明，这种动物是研究内分泌系统、生物节律、体温调节、感觉、大脑和认知功能随年龄变化的独特模型。
