Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, McGill University, Montreal, Canada.
Oral Oncol. 2011 Sep;47(9):783-91. doi: 10.1016/j.oraloncology.2011.07.004. Epub 2011 Jul 29.
Cancer of the oral cavity accounts for almost 3% of cancer cases in the world. The incidence varies widely reflecting geographic differences in exposure to risk factors. The recent rise in younger age groups and females seen in many countries is of particular concern. Treatment and management of complications, locoregional recurrence and further primary tumors result in high morbidity and mortality especially when the disease is advanced stage at initial diagnosis. Progress in cancer research has provided abundant new knowledge about cellular processes and molecular biology underlying oral carcinogenesis and tumor progression. The present review attempts to summarize the current most widely-used research approaches and their application in the prevention, diagnosis, effective treatment, and improved outcome of oral cancer.
口腔癌约占全球癌症病例的 3%。其发病率差异很大，反映了不同地区接触危险因素的差异。在许多国家，年轻人和女性的发病率最近有所上升，这尤其令人担忧。治疗和管理并发症、局部区域复发和进一步的原发性肿瘤会导致高发病率和死亡率，尤其是在疾病初始诊断时已处于晚期阶段。癌症研究的进展为口腔癌发生和肿瘤进展的细胞过程和分子生物学提供了丰富的新知识。本综述试图总结目前最广泛使用的研究方法及其在口腔癌的预防、诊断、有效治疗和改善预后中的应用。
