Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave., Boston, MA 02111, USA.
Curr Opin Microbiol. 2011 Aug;14(4):386-91. doi: 10.1016/j.mib.2011.07.015. Epub 2011 Jul 28.
Candida organisms commonly colonize the human gastrointestinal tract as a component of the resident microbiota. Their presence is generally benign. Recent studies, however, show that high level Candida colonization is associated with several diseases of the gastrointestinal tract. Further, results from animal models argue that Candida colonization delays healing of inflammatory lesions and that inflammation promotes colonization. These effects may create a vicious cycle in which low-level inflammation promotes fungal colonization and fungal colonization promotes further inflammation. Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL-17. Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation. Because Candida is a frequent colonizer, these effects have the potential to impact many people.
念珠菌属生物体通常作为常驻微生物群落的一部分定植于人体胃肠道。其存在通常是良性的。然而，最近的研究表明，高水平的念珠菌定植与几种胃肠道疾病有关。此外，动物模型的结果表明，念珠菌定植会延迟炎症病变的愈合，而炎症会促进定植。这些影响可能形成一个恶性循环，即低度炎症促进真菌定植，而真菌定植又促进进一步的炎症。炎症性肠病和胃肠道念珠菌定植均与促炎细胞因子 IL-17 水平升高有关。因此，念珠菌定植增强炎症的能力可能与 IL-17 水平的变化有关。由于念珠菌是一种常见的定植菌，这些影响有可能影响很多人。
