Neira-Egea Patricia, Alamar Malvoisin Clara, de la Cuesta-Torrado María, Bautista-Erler Claudia, Vitale Valentina, Jolly Sandra, Cesarini Carla
Department of Animal Medicine and Surgery, Institute of Biomedical Sciences, Cardenal Herrera-CEU University, CEU Universities, 46115 Alfara del Patriarca, Spain.
Equine Clinical Department & Fundamental and Applied Research for Animals & Health (FARAH), Faculty of Veterinary Medicine, University of Liège, Bât. B41, 4000 Liège, Belgium.
Microorganisms. 2025 Jul 25;13(8):1746. doi: 10.3390/microorganisms13081746.
spp. are ubiquitous yeasts that are part of most mammals' microbiota and can become opportunistic pathogens under predisposing conditions. Interestingly, recent studies in human medicine report an increased abundance of spp. in association with inflammatory bowel disease (IBD). Gastrointestinal candidiasis has been primarily reported in neonatal foals, but not in adult horses. The aim of this study is to describe the morphological, histopathological, and microbiological features of gastric lesions associated with infiltration in five horses referred to two tertiary hospitals for different reasons. Clinical features, findings from gastroscopy, gastric, and duodenal biopsies, as well as fungal and bacterial cultures obtained from gastric lesions will be reported. Macroscopically, gastric lesions showed a characteristic yellow/white pseudo-membranous appearance, similar to lesions reported in foals. The presence of spp. was confirmed by positive culture and/or histopathological evidence of fungal infiltration on the gastric epithelium. Three out of five horses showed histopathological changes in duodenal biopsies, potentially suggesting IBD. These results demonstrate that gastric candidiasis can occur in adult horses. Further research is needed to elucidate the pathogenesis, predisposing factors, and clinical relevance of spp. infections in the equine stomach, as well as their potential impact on gastrointestinal health and overall performance.
某属酵母菌是普遍存在的酵母，是大多数哺乳动物微生物群的一部分，在易感条件下可成为机会致病菌。有趣的是，最近在人类医学领域的研究报告称，某属酵母菌在炎症性肠病（IBD）患者中的丰度有所增加。胃肠道念珠菌病主要在新生马驹中报道过，但成年马中未见报道。本研究的目的是描述五匹因不同原因转诊至两家三级医院的马匹中，与某属酵母菌浸润相关的胃部病变的形态学、组织病理学和微生物学特征。将报告临床特征、胃镜检查结果、胃和十二指肠活检结果，以及从胃部病变中获得的真菌和细菌培养结果。宏观上，胃部病变呈现出特征性的黄/白色假膜外观，与马驹中报道的病变相似。通过阳性培养和/或胃上皮真菌浸润的组织病理学证据证实了某属酵母菌的存在。五匹马中有三匹在十二指肠活检中显示出组织病理学变化，这可能提示患有IBD。这些结果表明成年马也可发生胃部念珠菌病。需要进一步研究以阐明某属酵母菌在马胃中感染的发病机制、易感因素和临床相关性，以及它们对胃肠道健康和整体性能的潜在影响。
