筋骨草对白化病大鼠急慢性关节炎模型的抗关节炎作用。
Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats.
作者信息
Kaithwas Gaurav, Gautam Raju, Jachak Sanjay M, Saklani Arvind
机构信息
Department of Pharmaceutical Sciences, Assam University, Silchar-788 011, Assam, India.
出版信息
Asian Pac J Trop Biomed. 2012 Mar;2(3):185-8. doi: 10.1016/S2221-1691(12)60039-2.
Abstract
OBJECTIVE
To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats.
METHODS
The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund's adjuvant (CFA)-induced chronic immunological arthritis in albino rats.
RESULTS
EEAB showed a significant (P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis. EEAB exhibited better antiarthritic activity than the standard aspirin.
CONCLUSIONS
EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.
摘要
目的
使用白化大鼠评估苞片筋骨草的抗关节炎活性。
方法
评估苞片筋骨草70%乙醇提取物（EEAB）对白化大鼠由松节油和甲醛诱导的急性非免疫性关节炎以及由完全弗氏佐剂（CFA）诱导的慢性免疫性关节炎的抗关节炎活性。
结果
EEAB对急性和慢性关节炎模型均显示出显著（P<0.05）且剂量依赖性的抑制作用。EEAB表现出比标准阿司匹林更好的抗关节炎活性。
结论
EEAB对急性和慢性关节炎均表现出显著且有前景的抗关节炎活性，支持了苞片筋骨草在治疗风湿和其他炎症性疾病方面的传统用途。
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