J Toxicol Sci. 2011 Aug;36(4):453-60. doi: 10.2131/jts.36.453.
This study aimed to determine the cardiac and autonomic nervous effects of deoxynivalenol (DON), a representative mycotoxin which frequently contaminates cereal grains, in conscious rats that had been implanted with telemetric transmitters. Four groups of rats given subcutaneous injections of 0.5, 1.0, or 2.0 mg/kg of DON or propylene glycol (vehicle solution) were used in the experiments. Telemetric electrocardiogram (ECG) recordings were performed for 2 weeks or longer during the pre- and post-DON injection period. The present study demonstrated that DON caused marked arrhythmias, such as second-degree atrioventricular block, atrial bradycardia, supraventricular extrasystole, and ventricular extrasystole, at 3 hr or later (mostly at 10-20 hr) after the DON-injection, which were accompanied by a significant increase in heart rate (HR) and a significant decrease in total power and low- and high-frequency power during the period from 90 to 180 min after the injection. In conclusion, it was elucidated that DON produces significant cardiac dysfunction and transient inhibition of the autonomic nervous function in conscious rats at a dose of 0.5 mg/kg s.c. or more.
本研究旨在确定脱氧雪腐镰刀菌烯醇（DON），一种经常污染谷物的代表性真菌毒素，对植入遥测发射器的清醒大鼠的心脏和自主神经的影响。实验中使用了四组皮下注射 0.5、1.0 或 2.0mg/kg DON 或丙二醇（载体溶液）的大鼠。在 DON 注射前后的 2 周或更长时间内进行遥测心电图（ECG）记录。本研究表明，DON 在注射后 3 小时或更晚（大多在 10-20 小时）引起明显的心律失常，如二度房室传导阻滞、心房心动过缓、室上性期外收缩和室性期外收缩，同时心率显著增加，注射后 90 至 180 分钟期间总功率和低频及高频功率显著降低。总之，研究结果表明 DON 在 0.5mg/kg 或更高剂量的皮下注射时，可导致清醒大鼠产生明显的心脏功能障碍和自主神经功能短暂抑制。
