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表现为斑秃的系统性红斑狼疮

Systemic Lupus Erythematosus Presenting as Alopecia Areata.

作者信息

Forouzan Parnia, Cohen Philip R

机构信息

Dermatology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, USA.

Dermatology, San Diego Family Dermatology, National City, USA.

出版信息

Cureus. 2020 Jun 20;12(6):e8724. doi: 10.7759/cureus.8724.

DOI:10.7759/cureus.8724
PMID:32699719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7372242/
Abstract

Alopecia areata is an inflammatory, non-scarring hair loss associated with autoimmune conditions. It is more commonly seen with thyroid disorders and vitiligo, but alopecia areata has also been linked to diabetes, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus. Indeed, individuals with alopecia areata have an increased risk of developing systemic lupus erythematosus. A 36-year-old woman presented with hair loss characteristic of alopecia areata. After intralesional injections with triamcinolone acetonide, the areas of hair loss exhibited near complete hair regrowth. Laboratory examination and additional history were suggestive of systemic lupus erythematosus. She was referred to a rheumatologist who confirmed the diagnosis. Awareness of the comorbidities associated with alopecia areata can uncover other autoimmune conditions, such as thyroid disorders and systemic lupus erythematosus. The diagnosis of a new-onset alopecia areata may prompt a deeper investigation of potentially associated conditions.

摘要

斑秃是一种与自身免疫性疾病相关的炎症性、非瘢痕性脱发。它更常见于甲状腺疾病和白癜风,但斑秃也与糖尿病、银屑病、类风湿性关节炎和系统性红斑狼疮有关。事实上,斑秃患者患系统性红斑狼疮的风险增加。一名36岁女性出现斑秃特征性的脱发。在皮损内注射曲安奈德后,脱发区域几乎完全重新长出头发。实验室检查和进一步询问病史提示患有系统性红斑狼疮。她被转诊给一位风湿病学家,后者确诊了该疾病。认识到与斑秃相关的合并症可以发现其他自身免疫性疾病,如甲状腺疾病和系统性红斑狼疮。新发斑秃的诊断可能会促使对潜在相关疾病进行更深入的调查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3344/7372242/593bf841d32e/cureus-0012-00000008724-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3344/7372242/a096a79713b0/cureus-0012-00000008724-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3344/7372242/593bf841d32e/cureus-0012-00000008724-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3344/7372242/a096a79713b0/cureus-0012-00000008724-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3344/7372242/593bf841d32e/cureus-0012-00000008724-i02.jpg

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本文引用的文献

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New Criteria for Lupus.狼疮的新诊断标准
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2
Is there an association between alopecia areata and systemic lupus erythematosus? A population-based study.斑秃与红斑狼疮之间是否存在关联?一项基于人群的研究。
Immunol Res. 2020 Feb;68(1):1-6. doi: 10.1007/s12026-020-09115-x.
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Alopecias in lupus erythematosus.红斑狼疮中的脱发症
ABO血型和Rh血型与斑秃之间的关系。
Dermatol Pract Concept. 2023 Jan 1;13(1):e2023060. doi: 10.5826/dpc.1301a60.
4
Epidemiological, Clinical, Trichoscopic, and Histopathological Features of Lupus Erythematous Mimicking Alopecia Areata: A Multicenter Retrospective Study.模仿斑秃的红斑狼疮的流行病学、临床、毛发镜及组织病理学特征:一项多中心回顾性研究
Skin Appendage Disord. 2022 May;8(3):236-240. doi: 10.1159/000520825. Epub 2022 Jan 3.
5
A Retrospective Comparative Study of Two Concentrations of Intralesional Triamcinolone Acetonide in the Treatment of Patchy Alopecia Areata on the Scalp.两种浓度曲安奈德局部注射治疗头皮斑秃的回顾性对比研究
Clin Cosmet Investig Dermatol. 2020 Nov 2;13:795-803. doi: 10.2147/CCID.S280855. eCollection 2020.
Lupus Sci Med. 2018 Oct 25;5(1):e000291. doi: 10.1136/lupus-2018-000291. eCollection 2018.
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Comorbidities in alopecia areata: A systematic review and meta-analysis.斑秃的合并症:系统评价和荟萃分析。
J Am Acad Dermatol. 2019 Feb;80(2):466-477.e16. doi: 10.1016/j.jaad.2018.07.013. Epub 2018 Jul 18.
5
Alopecia Areata: Review of Epidemiology, Clinical Features, Pathogenesis, and New Treatment Options.斑秃:流行病学、临床特征、发病机制及新治疗选择综述
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6
Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.斑秃:疾病特征、临床评估及发病机制的新观点。
J Am Acad Dermatol. 2018 Jan;78(1):1-12. doi: 10.1016/j.jaad.2017.04.1141.
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Alopecia Areata. Current situation and perspectives.斑秃。现状与展望。
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Alopecia Areata of the Beard: A Review of the Literature.《胡须斑秃:文献回顾》。
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