使用聚硅烷负载钯/氧化铝杂化催化剂的连续流动氢化反应。
Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts.
机构信息
Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Beilstein J Org Chem. 2011;7:735-9. doi: 10.3762/bjoc.7.83. Epub 2011 May 31.
Continuous flow systems for hydrogenation using polysilane-supported palladium/alumina (Pd/(PSi-Al(2)O(3))) hybrid catalysts were developed. Our original Pd/(PSi-Al(2)O(3)) catalysts were used successfully in these systems and the hydrogenation of unsaturated C-C bonds and a nitro group, deprotection of a carbobenzyloxy (Cbz) group, and a dehalogenation reaction proceeded smoothly. The catalyst retained high activity for at least 8 h under neat conditions.
开发了用于氢化的连续流系统，使用了聚硅烷负载钯/氧化铝（Pd/（PSi-Al2O3））混合催化剂。我们的原始 Pd/（PSi-Al2O3）催化剂在这些系统中成功使用，不饱和 C-C 键和硝基的氢化、碳苄氧基（Cbz）基团的脱保护以及脱卤反应顺利进行。在纯条件下，催化剂至少保持 8 小时的高活性。
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