基底神经节作为安非他明多种作用的底物。
The Basal Ganglia as a Substrate for the Multiple Actions of Amphetamines.
作者信息
Natarajan Reka, Yamamoto Bryan K
机构信息
Department of Neurosciences University of Toledo College of Medicine Toledo, Ohio 43614.
出版信息
Basal Ganglia. 2011 Jul 1;1(2):49-57. doi: 10.1016/j.baga.2011.05.003.
Abstract
Amphetamines are psychostimulant drugs with high abuse potential. Acute and chronic doses of amphetamines affect dopamine (DA) neurotransmission in the basal ganglia. The basal ganglia are a group of subcortical nuclei that are anatomically positioned to integrate cognitive, motor and sensorimotor inputs from the cortex. Amphetamines can differentially alter the functioning of specific BG circuits to produce neurochemical changes that affect cognition, movement, and drug seeking behavior through their effects on DA neurotransmission. This review focuses on how alterations in dopaminergic neurotransmission within distinct basal ganglia pathways can modify their functional output to predict and explain the acute and long term behavioral consequences of amphetamine exposure.
摘要
安非他命是具有高度滥用潜力的精神刺激药物。急性和慢性剂量的安非他命会影响基底神经节中的多巴胺（DA）神经传递。基底神经节是一组皮质下核团，其解剖位置能够整合来自皮质的认知、运动和感觉运动输入。安非他命可以差异性地改变特定基底神经节回路的功能，通过其对DA神经传递的影响产生影响认知、运动和觅药行为的神经化学变化。本综述重点关注不同基底神经节通路中多巴胺能神经传递的改变如何改变其功能输出，以预测和解释安非他命暴露的急性和长期行为后果。
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1
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Early Interv Psychiatry. 2011 Feb;5(1):24-32. doi: 10.1111/j.1751-7893.2010.00254.x.
2
Cortical and basal ganglia contributions to habit learning and automaticity.
Trends Cogn Sci. 2010 May;14(5):208-15. doi: 10.1016/j.tics.2010.02.001. Epub 2010 Mar 5.
3
Amphetamine toxicities: classical and emerging mechanisms.
Ann N Y Acad Sci. 2010 Feb;1187:101-21. doi: 10.1111/j.1749-6632.2009.05141.x.
4
Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat.
PLoS One. 2010 Jan 20;5(1):e8790. doi: 10.1371/journal.pone.0008790.
5
Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum.
Neuropharmacology. 2010 Jun;58(7):951-61. doi: 10.1016/j.neuropharm.2010.01.008. Epub 2010 Jan 21.
6
Opposite effects of stimulant and antipsychotic drugs on striatal fast-spiking interneurons.
Neuropsychopharmacology. 2010 May;35(6):1261-70. doi: 10.1038/npp.2009.226. Epub 2010 Jan 20.
7
Prevalence of psychotic symptoms in substance users: a comparison across substances.
Compr Psychiatry. 2009 May-Jun;50(3):245-50. doi: 10.1016/j.comppsych.2008.07.009. Epub 2008 Sep 23.
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10
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