University of Prince Edward Island, Department of Physics, Charlottetown, Prince Edward Island Canada C1A 4P3.
J Biomed Opt. 2011 Jul;16(7):077003. doi: 10.1117/1.3597624.
Interstitial fiber-optic-based approaches used in both diagnostic and therapeutic applications rely on localized light-tissue interactions. We present an optical technique to identify spectrally and spatially specific exogenous chromophores in highly scattering turbid media. Point radiance spectroscopy is based on directional light collection at a single point with a side-firing fiber that can be rotated up to 360 deg. A side firing fiber accepts light within a well-defined, solid angle, thus potentially providing an improved spatial resolution. Measurements were performed using an 800-μm diameter isotropic spherical diffuser coupled to a halogen light source and a 600 μm, ∼43 deg cleaved fiber (i.e., radiance detector). The background liquid-based scattering phantom was fabricated using 1% Intralipid. Light was collected with 1 deg increments through 360 deg-segment. Gold nanoparticles , placed into a 3.5-mm diameter capillary tube were used as localized scatterers and absorbers introduced into the liquid phantom both on- and off-axis between source and detector. The localized optical inhomogeneity was detectable as an angular-resolved variation in the radiance polar plots. This technique is being investigated as a potential noninvasive optical modality for prostate cancer monitoring.
在诊断和治疗应用中使用的基于间质光纤的方法依赖于局部的光-组织相互作用。我们提出了一种光学技术，用于在高度散射的混浊介质中识别光谱和空间上特定的外源性发色团。点辐射光谱学基于在单个点处进行定向光收集，使用侧射光纤，可以旋转 360 度。侧射光纤在明确定义的立体角内接收光，因此可以提供更好的空间分辨率。测量是使用与卤素光源耦合的 800μm 直径各向同性球形漫射器和 600μm、约 43 度切割光纤（即辐射探测器）进行的。基于液体的散射体散射体是使用 1%的 Intralipid 制成的。通过 360 度分段以 1 度的增量收集光。金纳米颗粒，放置在 3.5mm 直径的毛细管中，用作局部散射体和吸收体，在源和探测器之间的轴上和轴外引入到液体体散射体中。局部光学不均匀性可以作为辐射极坐标图中角度分辨的变化来检测。这项技术正在被研究作为一种潜在的非侵入性光学方法用于前列腺癌监测。
