饮食与体外受精初步研究：短期体重减轻可提高接受体外受精的超重/肥胖女性的妊娠率。
Diet and IVF pilot study: short-term weight loss improves pregnancy rates in overweight/obese women undertaking IVF.
作者信息
Moran Lisa, Tsagareli Victoria, Norman Robert, Noakes Manny
机构信息
School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, The Robinson Institute, University of Adelaide, South Australia, Australia.
出版信息
Aust N Z J Obstet Gynaecol. 2011 Oct;51(5):455-9. doi: 10.1111/j.1479-828X.2011.01343.x. Epub 2011 Jul 19.
Obesity worsens and modest weight loss improves female fertility. Overweight women were randomised to lifestyle or standard treatment pre-in vitro fertilisation with treatment cessation at embryo transfer. There was a greater reduction in weight (P < 0.001) for lifestyle treatment (-3.8 ± 3.0 kg, P < 0.001) compared with no changes for standard treatment (-0.5 ± 1.2 kg, P = 0.092). Both the intervention (-5.3 ± 4.6 cm) and control (-3.5 ± 3.5 cm) group had reductions in waist circumference (P < 0.001) with no differences between the two groups (P = 0.215). The overall pregnancy rate was 53% (20/38) for the intervention and control group combined.
肥胖会使女性生育能力恶化，适度减重则可改善生育能力。超重女性在体外受精前被随机分配至生活方式干预组或标准治疗组，胚胎移植时停止治疗。与标准治疗组体重无变化（-0.5±1.2千克，P=0.092）相比，生活方式治疗组体重下降幅度更大（-3.8±3.0千克，P<0.001）（P<0.001）。干预组（-5.3±4.6厘米）和对照组（-3.5±3.5厘米）腰围均减小（P<0.001），两组间无差异（P=0.215）。干预组和对照组合并后的总体妊娠率为53%（20/38）。
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