Moran Lisa, Tsagareli Victoria, Norman Robert, Noakes Manny
School of Paediatrics and Reproductive Health, Research Centre for Reproductive Health, The Robinson Institute, University of Adelaide, South Australia, Australia.
Aust N Z J Obstet Gynaecol. 2011 Oct;51(5):455-9. doi: 10.1111/j.1479-828X.2011.01343.x. Epub 2011 Jul 19.
Obesity worsens and modest weight loss improves female fertility. Overweight women were randomised to lifestyle or standard treatment pre-in vitro fertilisation with treatment cessation at embryo transfer. There was a greater reduction in weight (P < 0.001) for lifestyle treatment (-3.8 ± 3.0 kg, P < 0.001) compared with no changes for standard treatment (-0.5 ± 1.2 kg, P = 0.092). Both the intervention (-5.3 ± 4.6 cm) and control (-3.5 ± 3.5 cm) group had reductions in waist circumference (P < 0.001) with no differences between the two groups (P = 0.215). The overall pregnancy rate was 53% (20/38) for the intervention and control group combined.
肥胖会使女性生育能力恶化，适度减重则可改善生育能力。超重女性在体外受精前被随机分配至生活方式干预组或标准治疗组，胚胎移植时停止治疗。与标准治疗组体重无变化（-0.5±1.2千克，P=0.092）相比，生活方式治疗组体重下降幅度更大（-3.8±3.0千克，P<0.001）（P<0.001）。干预组（-5.3±4.6厘米）和对照组（-3.5±3.5厘米）腰围均减小（P<0.001），两组间无差异（P=0.215）。干预组和对照组合并后的总体妊娠率为53%（20/38）。
