作为减肥饮食计划的一部分，全谷物即食燕麦片比包含低纤维对照食品的饮食计划更能降低超重和肥胖成年人的低密度脂蛋白胆固醇。

Whole-grain ready-to-eat oat cereal, as part of a dietary program for weight loss, reduces low-density lipoprotein cholesterol in adults with overweight and obesity more than a dietary program including low-fiber control foods.

作者信息

Maki Kevin C, Beiseigel Jeannemarie M, Jonnalagadda Satya S, Gugger Carolyn K, Reeves Matthew S, Farmer Mildred V, Kaden Valerie N, Rains Tia M

机构信息

Provident Clinical Research, Glen Ellyn, IL 60137, USA.

出版信息

J Am Diet Assoc. 2010 Feb;110(2):205-14. doi: 10.1016/j.jada.2009.10.037.

DOI:10.1016/j.jada.2009.10.037

PMID:20102847

Abstract

OBJECTIVE

Weight loss and consumption of viscous fibers both lower low-density lipoprotein (LDL) cholesterol levels. We evaluated whether or not a whole-grain, ready-to-eat (RTE) oat cereal containing viscous fiber, as part of a dietary program for weight loss, lowers LDL cholesterol levels and improves other cardiovascular disease risk markers more than a dietary program alone.

DESIGN

Randomized, parallel-arm, controlled trial.

SUBJECTS/SETTING: Free-living, overweight and obese adults (N=204, body mass index 25 to 45) with baseline LDL cholesterol levels 130 to 200 mg/dL (3.4 to 5.2 mmol/L) were randomized; 144 were included in the main analysis of participants who completed the trial without significant protocol violations.

INTERVENTION

Two portions per day of whole-grain RTE oat cereal (3 g/day oat b-glucan) or energy-matched low-fiber foods (control), as part of a reduced energy ( approximately 500 kcal/day deficit) dietary program that encouraged limiting consumption of foods high in energy and fat, portion control, and regular physical activity.

MAIN OUTCOME MEASURES

Fasting lipoprotein levels, waist circumference, triceps skinfold thickness, and body weight were measured at baseline and weeks 4, 8, 10, and 12.

RESULTS

LDL cholesterol level was reduced significantly more with whole-grain RTE oat cereal vs control (-8.7+/-1.0 vs -4.3+/-1.1%, P=0.005). Total cholesterol (-5.4+/-0.8 vs -2.9+/-0.9%, P=0.038) and non-high-density lipoprotein-cholesterol (-6.3+/-1.0 vs -3.3+/-1.1%, P=0.046) were also lowered significantly more with whole-grain RTE oat cereal, whereas high-density lipoprotein and triglyceride responses did not differ between groups. Weight loss was not different between groups (-2.2+/-0.3 vs -1.7+/-0.3 kg, P=0.325), but waist circumference decreased more (-3.3+/-0.4 vs -1.9+/-0.4 cm, P=0.012) with whole-grain RTE oat cereal. Larger reductions in LDL, total, and non-high-density lipoprotein cholesterol levels and waist circumference were evident as early as week 4 in the whole-grain RTE oat cereal group.

CONCLUSIONS

Consumption of a whole-grain RTE oat cereal as part of a dietary program for weight loss had favorable effects on fasting lipid levels and waist circumference.

摘要

目的

体重减轻和食用粘性纤维均可降低低密度脂蛋白（LDL）胆固醇水平。我们评估了一种含有粘性纤维的即食全谷物燕麦片作为减肥饮食计划的一部分，与单纯的饮食计划相比，是否能更有效地降低LDL胆固醇水平并改善其他心血管疾病风险指标。

设计

随机、平行组、对照试验。

受试者/研究地点：204名自由生活的超重和肥胖成年人（体重指数为25至45），基线LDL胆固醇水平为130至200mg/dL（3.4至5.2mmol/L），被随机分组；144名未违反研究方案且完成试验的参与者纳入主要分析。

干预措施

每天食用两份全谷物即食燕麦片（每天3g燕麦β-葡聚糖）或能量匹配的低纤维食物（对照组），作为减少能量摄入（每天约500千卡热量缺口）饮食计划的一部分，该计划鼓励限制高能量和高脂肪食物的摄入、控制食量并进行规律的体育活动。

主要观察指标

在基线以及第4、8、10和12周测量空腹脂蛋白水平、腰围、肱三头肌皮褶厚度和体重。

结果

与对照组相比，全谷物即食燕麦片组的LDL胆固醇水平显著降低更多（-8.7±1.0%对-4.3±1.1%，P=0.005）。全谷物即食燕麦片组的总胆固醇（-5.4±0.8%对-2.9±0.9%，P=0.038）和非高密度脂蛋白胆固醇（-6.3±1.0%对-3.3±1.1%，P=0.046）也显著降低更多，而两组之间的高密度脂蛋白和甘油三酯反应无差异。两组间体重减轻无差异（-2.2±0.3kg对-1.7±0.3kg，P=0.325），但全谷物即食燕麦片组的腰围下降更多（-3.3±0.4cm对-1.9±0.4cm，P=0.012）。早在第4周，全谷物即食燕麦片组的LDL、总胆固醇和非高密度脂蛋白胆固醇水平以及腰围就有更明显的降低。