Northwestern University Feinberg School of Medicine, Division of Gastroenterology, Chicago, IL 60611, USA.
Aliment Pharmacol Ther. 2011 Oct;34(7):790-8. doi: 10.1111/j.1365-2036.2011.04791.x. Epub 2011 Aug 2.
Eosinophilic oesophagitis (EoO) is a chronic disease characterised by significant symptoms and challenging treatment regimens. Health-related quality of life (HRQOL) is a useful way to direct patient care. EoO symptoms and treatment may impact patient HRQOL. Currently, there is no reliable and valid measure of adult EoO patient HRQOL.
To validate the Adult Eosinophilic Oesophagitis Quality of Life (EoO-QOL-A) questionnaire as a measure of HRQOL in this population.
The EoO patients aged 18-70 recruited via an out-patient GI clinic and two EoO advocacy groups completed the preliminary EoO-QOL-A, demographic and clinical information, and measures of general HRQOL, psychological distress and EoO symptom severity. A subset of patients completed test-retest assessments. Scale reliability, internal consistency, factor structure, concurrent and convergent validity were evaluated.
A total of 201 patients have participated. The study sample was primarily Caucasian, college-educated, and evenly split by gender. The average duration of disease was 7 years with duration of symptoms of 26 months prior to diagnosis. Patients reported were using both pharmacological and dietary treatments. Factor analysis yielded a 37-item, 5-factor structure: Eating/Diet Impact, Social Impact, Emotional Impact, Disease Anxiety and Choking Anxiety. The EoO-QOL-A demonstrated excellent internal consistency, split-half and test-retest reliability. Concurrent and convergent validity were supported by moderate correlations with established HRQOL measures, psychological distress and oesophageal symptoms.
The EoO-QOL-A is a valid and reliable disease-specific HRQOL measure for adult EoO patients. Developing the Adult Eosinophilic Oesophagitis Quality of Life is an important step in guiding treatment practices, improving disease education and standardising research protocols.
嗜酸性粒细胞性食管炎 (EoO) 是一种以显著症状和具有挑战性的治疗方案为特征的慢性疾病。健康相关生活质量 (HRQOL) 是指导患者护理的一种有用方法。EoO 症状和治疗可能会影响患者的 HRQOL。目前，尚无可靠和有效的成人 EoO 患者 HRQOL 衡量标准。
验证成人嗜酸性粒细胞性食管炎生活质量 (EoO-QOL-A) 问卷作为该人群 HRQOL 的衡量标准。
通过门诊胃肠科和两个 EoO 倡导组织招募年龄在 18-70 岁的 EoO 患者完成初步的 EoO-QOL-A、人口统计学和临床信息以及一般 HRQOL、心理困扰和 EoO 症状严重程度的测量。一部分患者完成了测试-重测评估。评估了量表的信度、内部一致性、因子结构、同时和收敛效度。
共有 201 名患者参与了研究。研究样本主要为白种人，受过大学教育，且性别比例均等。疾病平均持续时间为 7 年，症状持续时间在诊断前为 26 个月。患者报告同时使用药物和饮食治疗。因子分析产生了一个 37 项、5 因子结构：进食/饮食影响、社会影响、情绪影响、疾病焦虑和窒息焦虑。EoO-QOL-A 表现出极好的内部一致性、半分信度和重测信度。与既定的 HRQOL 测量、心理困扰和食管症状的中度相关性支持了同时和收敛效度。
EoO-QOL-A 是成人 EoO 患者的一种有效且可靠的疾病特异性 HRQOL 衡量标准。开发成人嗜酸性粒细胞性食管炎生活质量是指导治疗实践、改善疾病教育和标准化研究方案的重要步骤。
