Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Curr Opin Cell Biol. 2011 Oct;23(5):508-14. doi: 10.1016/j.ceb.2011.07.004. Epub 2011 Jul 30.
Recent advances in microscopy techniques and biophysical measurements have provided novel insight into the molecular, cellular and biophysical basis of cell adhesion. However, comparably little is known about a core element of cell-cell adhesion--the energy of adhesion at the cell-cell contact. In this review, we discuss approaches to understand the nature and regulation of adhesion energy, and propose strategies to determine adhesion energy between cells in vitro and in vivo.
近年来，显微镜技术和生物物理测量的进步为细胞黏附的分子、细胞和生物物理基础提供了新的认识。然而，对于细胞-细胞黏附的一个核心要素——细胞-细胞接触处的黏附能，我们的了解相对较少。在这篇综述中，我们讨论了理解黏附能的性质和调节的方法，并提出了在体外和体内确定细胞间黏附能的策略。
