Massachusetts General Hospital Center for Cancer Research and Harvard Medical School Department of Pathology, Charlestown, MA, USA.
Curr Opin Cell Biol. 2012 Oct;24(5):685-94. doi: 10.1016/j.ceb.2012.06.009. Epub 2012 Jul 24.
It has long been appreciated that proliferation of many cells is inhibited by density, a phenomenon that is often attributed to cell-cell contact. The basic properties of this phenomenon were established in the 1960s, along with the observation that such density-dependence was also lost in transformed cells. The mechanistic basis of contact inhibition of proliferation (CIP) has been slower to reveal itself. Here we discuss recent progress in elucidating the roles that cell-cell adhesion molecules play as receptors for CIP and in characterising the intracellular signaling pathways that mediate adhesion-dependent proliferative inhibition.
长期以来，人们已经认识到许多细胞的增殖受到密度的抑制，这种现象通常归因于细胞-细胞接触。这种现象的基本特性是在 20 世纪 60 年代确立的，同时也观察到这种密度依赖性也在转化细胞中丧失。接触抑制增殖（CIP）的机制基础揭示得比较慢。在这里，我们讨论了阐明细胞-细胞黏附分子作为 CIP 受体的作用以及描述介导黏附依赖性增殖抑制的细胞内信号通路的最新进展。
