广西莪术中二芳庚烷类化合物及其对脂多糖激活巨噬细胞一氧化氮生成的抑制活性。
Diarylheptanoids from Curcuma kwangsiensis and their inhibitory activity on nitric oxide production in lipopolysaccharide-activated macrophages.
机构信息
Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
出版信息
Bioorg Med Chem Lett. 2011 Sep 15;21(18):5363-9. doi: 10.1016/j.bmcl.2011.07.012. Epub 2011 Jul 18.
Eleven diarylheptanoids (1-11) were isolated from rhizomes of Curcuma kwangsiensis, together with seven known compounds. Their structures were elucidated by 1D and 2D NMR, circular dichroism (CD), and accurate mass measurements. Inhibitory effects of the isolated compounds on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated. Compounds 1, 2, and 3 showed strong inhibitory activity on NO production with IC(50) values of 3.13, 2.81 and 2.41 μM, respectively.
从广西莪术根茎中分离得到 11 个二芳基庚烷类化合物（1-11），同时还分离得到了 7 个已知化合物。通过一维和二维 NMR、圆二色性（CD）和精确质量测量等方法确定了它们的结构。评估了分离得到的化合物对脂多糖激活的巨噬细胞中一氧化氮生成的抑制作用。化合物 1、2 和 3 对 NO 生成具有较强的抑制活性，IC50 值分别为 3.13、2.81 和 2.41 μM。
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