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从广西莪术根茎中分离得到的五种新二芳基庚烷类化合物及其抗增殖活性。

Five new diarylheptanoids from the rhizomes of Curcuma kwangsiensis and their antiproliferative activity.

作者信息

Chen Shao-Dan, Gao Jin-Tao, Liu Jing-Gong, Liu Bo, Zhao Rui-Zhi, Lu Chuan-Jian

机构信息

The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China; Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.

出版信息

Fitoterapia. 2015 Apr;102:67-73. doi: 10.1016/j.fitote.2015.02.004. Epub 2015 Feb 20.

DOI:10.1016/j.fitote.2015.02.004
PMID:25704367
Abstract

Five new diarylheptanoids (1-5), along with nine known ones (6-14), were isolated from the rhizomes of Curcuma kwangsiensis. Their structures were established on the basis of spectroscopic analyses. Compounds 1-3 were cyclic diarylheptanoids rarely discovered from C. kwangsiensis. Of all the isolated compounds, compound 4 showed moderate antiproliferative activity on HH and HaCaT cells.

摘要

从广西莪术根茎中分离得到5个新的二芳基庚烷类化合物（1-5）以及9个已知化合物（6-14）。通过光谱分析确定了它们的结构。化合物1-3是从广西莪术根茎中罕见发现的环状二芳基庚烷类化合物。在所有分离得到的化合物中，化合物4对HH和HaCaT细胞显示出中等程度的抗增殖活性。

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