Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Suwon, Gyeonggi-do 440-746, Republic of Korea.
Bioorg Med Chem Lett. 2013 Jul 1;23(13):3806-9. doi: 10.1016/j.bmcl.2013.04.073. Epub 2013 May 7.
In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3-12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1-12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 μM, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells.
在继续从薯蓣科药用植物中寻找生物活性成分的过程中，从穿龙薯蓣的根茎中分离得到了两个新的环状二芳基庚烷类化合物，分别命名为 diosniponol A（1）和 B（2），以及 10 个已知化合物（3-12）。这些新化合物的结构通过光谱分析确定，包括广泛的二维核磁共振、高分辨率质谱和旋光。所有分离得到的化合物 1-12 都进行了评估，以检测它们对小鼠小胶质细胞系 BV-2 中一氧化氮（NO）产生的影响。化合物 8 和 11 在脂多糖激活的 BV-2 细胞中表现出对 NO 产生的强烈抑制活性（IC50 分别为 13.36 和 14.36 μM），且没有细胞毒性。
