夜间工作与炎症标志物
Night work and inflammatory markers.
作者信息
Khosro Sadeghniiat, Alireza Safaiyan, Omid Aminian, Forough Sharifi
机构信息
Department of Occupational Medicine, Baharlou Hospital, Tehran University of Medical Sciences, Iran.
出版信息
Indian J Occup Environ Med. 2011 Jan;15(1):38-41. doi: 10.4103/0019-5278.82996.
BACKGROUND
Various adverse health effects associated with shift work have been documented in the medical literature. These include increased risk of cardiovascular disorders, cerebrovascular disorders, and mortality. Sleep deprivation has been shown to be associated with an elevation in inflammatory makers such as interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). It is hypothesized that the increased risk of many disorders associated with shift work may be due to inflammatory processes resulting from sleep deprivation. The purpose of this study was to investigate the relationship between night work and inflammatory markers.
MATERIALS AND METHODS
Fifty workers were selected according to the specified inclusion and exclusion criteria and randomly assigned to one of two groups in a cross over study. The 25 workers in group 1 were scheduled to work the following consecutive shifts: three day shifts, one day off, and three night shifts. Group 2 were scheduled to work the following consecutive shifts: three night shifts, one day off, and three day shifts. Blood samples were obtained between 7:A.M. and 8:A.M. after the periods of day work and night work and tested for inflammatory markers.
STATISTICAL ANALYSES
SPSS 11.5 and S-data were used to analyze data using the Student's t-test and paired t-test.
RESULTS
There was a statistically significant increase in IL-6, CRP, white blood cells, neutrophils, lymphocytes, and platelets following night work compared with day work. TNF-α was increased but it was not statistically significant, and also the change in monocyte counts was not significant.
CONCLUSION
This study demonstrated an increase in inflammatory markers following night work, as reported in several pervious studies on sleep deprivation. No significant changes in monocyte count can be justified by the results of a study which showed that the elevation in blood levels of inflammatory markers is due to increase in gene expression, not in monocyte counts.
背景
医学文献中已记录了与轮班工作相关的各种不良健康影响。这些包括心血管疾病、脑血管疾病和死亡率风险增加。睡眠剥夺已被证明与炎症标志物如白细胞介素6（IL-6）、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）升高有关。据推测，与轮班工作相关的许多疾病风险增加可能是由于睡眠剥夺导致的炎症过程。本研究的目的是调查夜班工作与炎症标志物之间的关系。
材料与方法
根据指定的纳入和排除标准选择50名工人，并在一项交叉研究中随机分配到两组中的一组。第1组的25名工人安排连续轮班如下：三个白班、一天休息和三个夜班。第2组安排连续轮班如下：三个夜班、一天休息和三个白班。在白班和夜班工作时段结束后，于上午7点至8点采集血样并检测炎症标志物。
统计分析
使用SPSS 11.5和S-data，采用学生t检验和配对t检验分析数据。
结果
与白班工作相比，夜班工作后IL-6、CRP、白细胞、中性粒细胞、淋巴细胞和血小板有统计学显著增加。TNF-α升高但无统计学显著性，单核细胞计数变化也不显著。
结论
本研究表明，如先前几项关于睡眠剥夺的研究所报道，夜班工作后炎症标志物增加。一项研究结果表明，炎症标志物血水平升高是由于基因表达增加而非单核细胞计数增加，因此单核细胞计数无显著变化是合理的。
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