烹饪香草罗勒叶提取物的抗惊厥和抗焦虑评估
Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb.
作者信息
Okoli C O, Ezike A C, Agwagah O C, Akah P A
机构信息
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka - 410 001, Enugu State, Nigeria.
出版信息
Pharmacognosy Res. 2010 Jan;2(1):36-40. doi: 10.4103/0974-8490.60580.
Abstract
Anticonvulsant and anxiolytic activities of leaf extracts and fraction of Ocimum gratissimum L. (Lamiaceae) were studied using seizures induced by pentylenetetrazol and open-field tests in mice. The results showed that the extracts and fraction increased the latency of tonic and tonic-clonic seizures and death and elicited 50% protection against mortality. In the open-field test, the extracts and fraction decreased the frequency of line crossing, center square entries, rearing against a wall and grooming, whereas grooming duration and freezing frequency and duration were increased. Acute toxicity test in mice gave an oral LD(50) greater than 5000 mg/kg for the methanol extract. These findings suggest that extracts of this plant possess anticonvulsant and anxiolytic-like properties.
摘要
采用戊四氮诱导的惊厥模型和小鼠旷场试验，研究了唇形科植物丁香罗勒叶提取物及其馏分的抗惊厥和抗焦虑活性。结果表明，提取物及其馏分可延长强直性和强直阵挛性惊厥发作的潜伏期及死亡时间，并对死亡率有50%的保护作用。在旷场试验中，提取物及其馏分可减少小鼠穿越格子数、进入中央格数、靠墙站立次数和理毛次数，同时增加理毛持续时间、静止频率和静止持续时间。小鼠急性毒性试验表明，甲醇提取物的经口半数致死量（LD50）大于5000 mg/kg。这些结果表明，该植物提取物具有抗惊厥和抗焦虑样特性。
相似文献
1
Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb.
Pharmacognosy Res. 2010 Jan;2(1):36-40. doi: 10.4103/0974-8490.60580.
2
Anticonvulsant and anxiolytic activity of the leaf aqueous and ethanolic extracts of in a rat model.
Afr J Pharm Pharmacol. 2016 Mar;10(12):216-222. doi: 10.5897/AJPP2015.4488.
3
Anticonvulsant activity of Nylandtia spinosa L. Dumont (Polygalaceae) aqueous and methanol leaf extracts in mice.
Hum Exp Toxicol. 2008 Nov;27(11):811-8. doi: 10.1177/0960327108099538.
4
leaf extract ameliorates phenylhydrazine-induced anaemia and toxicity in Wistar rats.
Drug Metab Pers Ther. 2021 Apr 9;36(4):311-320. doi: 10.1515/dmpt-2020-0185.
5
Anti-trypanosomal effects of aqueous extract of Ocimum gratissimum (Lamiaceae) leaf in rats infected with Trypanosoma brucei brucei.
Afr J Tradit Complement Altern Med. 2009 May 7;6(3):262-7.
6
Flavonoid-Rich Fraction of Ocimum gratissimum Attenuates Lipopolysaccharide-Induced Sickness Behavior, Inflammatory and Oxidative Stress in Mice.
Drug Res (Stuttg). 2019 Feb;69(3):151-158. doi: 10.1055/a-0654-5042. Epub 2018 Jul 31.
7
In vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage.
J Ethnopharmacol. 2014 Sep 29;155(3):1417-23. doi: 10.1016/j.jep.2014.07.014. Epub 2014 Jul 21.
8
Anxiolytic and anticonvulsant activity of methanol extract of leaves of Alternanthera brasiliana (L.) Kuntze (Amaranthaceae) in laboratory animals.
Indian J Exp Biol. 2013 Jun;51(6):450-7.
9
Non cholinergic dependent mechanism of Ocimum gratissimum induced neurobehavioural alterations in mice.
Afr J Med Med Sci. 2015 Sep;44(3):213-20.
10
Pharmacognostic profiles, evaluation of analgesic, anti-inflammatory and anticonvulsant activities of Newbouldia laevis (P. Beauv.) Seem. ex Bureau leaf and root extracts in Wistar rats.
J Ethnopharmacol. 2023 Oct 5;314:116632. doi: 10.1016/j.jep.2023.116632. Epub 2023 May 19.
引用本文的文献
1
Anti-apoptotic and antioxidant mechanisms may underlie the abrogative potential of Linn. Leaf extract and fractions against trastuzumab-induced cardiotoxicity in Wistar rats.
Toxicol Rep. 2024 Jan 18;12:200-214. doi: 10.1016/j.toxrep.2024.01.011. eCollection 2024 Jun.
2
Depression in Sub-Saharan Africa.
IBRO Neurosci Rep. 2022 Mar 17;12:309-322. doi: 10.1016/j.ibneur.2022.03.005. eCollection 2022 Jun.
3
A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil ( L.).
Heliyon. 2021 Nov 25;7(11):e08404. doi: 10.1016/j.heliyon.2021.e08404. eCollection 2021 Nov.
4
An Ethnobotanical Study on Qīng-Căo-Chá Tea in Taiwan.
Front Pharmacol. 2020 Jun 25;11:931. doi: 10.3389/fphar.2020.00931. eCollection 2020.
5
Insights about multi-targeting and synergistic neuromodulators in Ayurvedic herbs against epilepsy: integrated computational studies on drug-target and protein-protein interaction networks.
Sci Rep. 2019 Jul 22;9(1):10565. doi: 10.1038/s41598-019-46715-6.
6
Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana.
Evid Based Complement Alternat Med. 2018 Dec 20;2018:8590381. doi: 10.1155/2018/8590381. eCollection 2018.
7
Neuroprotective Strategies for Neurological Disorders by Natural Products: An update.
Curr Neuropharmacol. 2019;17(3):247-267. doi: 10.2174/1570159X16666180911124605.
8
Effect of Naringenin (A naturally occurring flavanone) Against Pilocarpine-induced Status Epilepticus and Oxidative Stress in Mice.
Pharmacogn Mag. 2017 Jan;13(Suppl 1):S154-S160. doi: 10.4103/0973-1296.203977. Epub 2017 Apr 7.
9
The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature.
Evid Based Complement Alternat Med. 2017;2017:9217567. doi: 10.1155/2017/9217567. Epub 2017 Mar 16.
10
aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters.
Int J Med Sci. 2016 Oct 18;13(11):819-824. doi: 10.7150/ijms.16474. eCollection 2016.
本文引用的文献
1
Effects of Hypericum perforatum L. and Hypericum calycinum L. extracts on the central nervous system in mice.
Phytomedicine. 1996 Sep;3(2):139-46. doi: 10.1016/S0944-7113(96)80027-4.
2
Anticonvulsant, analgesic and antipyretic activities of Taxus wallichiana Zucc.
J Ethnopharmacol. 2008 Mar 28;116(3):490-4. doi: 10.1016/j.jep.2007.12.021. Epub 2008 Jan 20.
3
The Open-Field Test: a critical review.
Psychol Bull. 1976 May;83(3):482-504.
4
Effects of seasonal variation on the central nervous system activity of Ocimum gratissimum L. essential oil.
J Ethnopharmacol. 2006 Apr 21;105(1-2):161-6. doi: 10.1016/j.jep.2005.10.013. Epub 2005 Nov 21.
5
Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice.
Braz J Med Biol Res. 2003 Apr;36(4):521-4. doi: 10.1590/s0100-879x2003000400016. Epub 2003 Apr 8.
6
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Eur J Pharmacol. 2003 Feb 28;463(1-3):3-33. doi: 10.1016/s0014-2999(03)01272-x.
7
Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) n.e. Brown.
Phytomedicine. 2002 Dec;9(8):709-14. doi: 10.1078/094471102321621304.
8
Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig.
J Ethnopharmacol. 2002 Jun;81(1):1-4. doi: 10.1016/s0378-8741(02)00049-1.
9
Medicinal plants popularly used in the Brazilian Tropical Atlantic Forest.
Fitoterapia. 2002 Feb;73(1):69-91. doi: 10.1016/s0367-326x(01)00362-8.
10
Shigellocidal properties of three Nigerian medicinal plants: Ocimum gratissimum, Terminalia avicennoides, and Momordica balsamina.
J Health Popul Nutr. 2001 Dec;19(4):331-5.
Zotero 插件