McAuley Edward, Szabo Amanda N, Mailey Emily L, Erickson Kirk I, Voss Michelle, White Siobhan M, Wójcicki Thomas R, Gothe Neha, Olson Erin A, Mullen Sean P, Kramer Arthur F
University of Illinois at Urbana-Champaign.
Ment Health Phys Act. 2011 Jun 1;4(1):5-11. doi: 10.1016/j.mhpa.2011.01.001.
There is increasing evidence that cardiorespiratory fitness (CRF) is associated with brain structure and function, and improvements in CRF through exercise training have been associated with neural and cognitive functioning in older adults. The objectives of this study were to validate the use of a non-exercise estimate of CRF, and to examine its association with cognitive function, brain structure and subjective memory complaints. Low active, older adults (N = 86; M age= 65.14) completed a physician-supervised maximal exercise test, a 1-mile timed walk, several measures of cognitive function, and a 3 Tesla structural MRI. Fitness was also calculated from an equation derived by (Jurca et al., 2005) based on age, sex, body mass index, resting heart rate, and self-reported physical activity level. Analyses indicated that all three measures of CRF were significantly correlated with one another. In addition, measures of cognitive function, hippocampus volume, and memory complaints were significantly correlated with each measure of fitness. These findings have implications for using a low-risk, low-cost, non-exercise estimate of CRF in determining fitness associations with brain structure and cognitive function in older adults. As such, this measure may have utility for larger population based studies. Further validation is required, as is determination of whether such relationships hold over the course of exercise interventions.
越来越多的证据表明，心肺适能（CRF）与脑结构和功能相关，通过运动训练改善CRF与老年人的神经和认知功能有关。本研究的目的是验证使用非运动方式估计CRF，并检查其与认知功能、脑结构和主观记忆主诉的关联。低活动水平的老年人（N = 86；平均年龄 = 65.14）完成了由医生监督的最大运动测试、1英里定时步行、多项认知功能测量以及3特斯拉结构MRI扫描。还根据（尤尔卡等人，2005年）推导的一个公式，基于年龄、性别、体重指数、静息心率和自我报告的身体活动水平计算适能。分析表明，所有三种CRF测量方法彼此之间均显著相关。此外，认知功能测量、海马体体积和记忆主诉与每种适能测量方法均显著相关。这些发现对于在确定老年人适能与脑结构和认知功能的关联时使用低风险、低成本的非运动方式估计CRF具有启示意义。因此，这种测量方法可能对基于更大人群的研究有用。需要进一步验证，同时也需要确定这些关系在运动干预过程中是否成立。
