de Leon Jose, Mallory Paula, Maw Lorraine, Susce Margaret T, Perez-Rodriguez M Mercedes, Baca-Garcia Enrique
Mental Health Research Center, Eastern State Hospital, 627 West Fourth Street, Lexington, KY 40508, USA.
Ann Clin Psychiatry. 2011 Aug;23(3):163-70.
In 2 Spanish case-control studies, low cholesterol levels in males were consistently associated with suicide attempts.
This US study tried to replicate the association between low cholesterol levels and suicide attempts, using a case-control design to study all patients admitted to Eastern State Hospital in Lexington, Kentucky, during a 1-year period. Psychiatric patients who had currently attempted suicide were studied as cases, and psychiatric patients who had not currently attempted suicide served as controls. A fasting serum total cholesterol <160 mg/dL was considered a possible risk factor for suicide. Logistic regression provided an adjusted estimate of the univariate odds ratios (ORs) for confounding factors.
There were 193 current suicide attempters (cases) and 1091 non-current suicide attempters (controls). In the total sample logistic regression model, low cholesterol levels were significantly associated with lower risk of current suicide attempt (OR, 0.60; confidence interval (CI), 0.39 to 0.92) after adjusting for confounding variables. After sex stratification, low cholesterol levels were significant only among men (OR, 0.47; CI, 0.26 to 0.86). This US study did not replicate our prior Spanish findings; to the contrary, low cholesterol levels were not associated with increased suicide risk but with a decreased risk in US men.
It is possible cholesterol abnormalities and low body mass index may be markers of suicide risk, particularly in some male patients.
在两项西班牙病例对照研究中，男性低胆固醇水平一直与自杀未遂相关。
这项美国研究试图通过病例对照设计来复制低胆固醇水平与自杀未遂之间的关联，研究肯塔基州列克星敦市东部州立医院在1年期间收治的所有患者。将目前有自杀未遂行为的精神科患者作为病例，目前没有自杀未遂行为的精神科患者作为对照。空腹血清总胆固醇<160mg/dL被视为自杀的一个可能危险因素。逻辑回归提供了对混杂因素的单变量比值比（OR）的校正估计。
共有193例目前有自杀未遂行为者（病例）和1091例目前无自杀未遂行为者（对照）。在总样本逻辑回归模型中，校正混杂变量后，低胆固醇水平与目前自杀未遂风险较低显著相关（OR，0.60；置信区间（CI），0.39至0.92）。按性别分层后，低胆固醇水平仅在男性中显著（OR，0.47；CI，0.26至0.86）。这项美国研究未能复制我们之前在西班牙的研究结果；相反，在美国男性中，低胆固醇水平与自杀风险增加无关，而是与风险降低有关。
胆固醇异常和低体重指数可能是自杀风险的标志物，尤其是在一些男性患者中。
