Department of Psychiatry, The Second Xiangya Hospital, Central South University, The China National Clinical Research Center for Mental Health Disorders, Chinese National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, No. 139, Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
Psychosomatic Health Institute of the Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
BMC Psychiatry. 2019 May 10;19(1):144. doi: 10.1186/s12888-019-2131-6.
Metabolic disturbances have been correlated with suicidality, but little is known about the association between suicide risk and metabolic disturbances among individuals with depression. This study was to evaluate the prevalence and clinical correlations, especially cardio-metabolic associated factors of recent suicide attempts in Chinese patients with major depressive disorder (MDD).
A total of 288 MDD inpatients were recruited. Their clinical and demographic data together with plasma glucose, lipid and thyroid function parameters were collected. Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS) and Eysenck Personality Questionnaire (EPQ) were rated for most of the patients.
Of these MDD inpatients, 20.14% had attempted suicide during the past 1 month. Compared to those who had not attempted suicide, the suicide attempters had a significantly longer duration of illness, lower low-density lipoprotein (LDL) cholesterol, lower total cholesterol, and more psychotic symptoms. However, all these significant results did not survive after the bonferroni correction (all p > 0.05). A logistic regression analysis indicated that suicide attempts were associated with the lower total cholesterol and more psychotic symptoms.
Our findings support the hypothesis of the association of low plasma cholesterol level and recent suicidal attempts in patients with MDD.
代谢紊乱与自杀意念相关，但对于抑郁症患者的自杀风险与代谢紊乱之间的关系知之甚少。本研究旨在评估中国重度抑郁症（MDD）患者近期自杀未遂的发生率及临床相关性，特别是与心脏代谢相关的因素。
共纳入 288 例 MDD 住院患者。收集了他们的临床和人口统计学数据，以及血浆葡萄糖、血脂和甲状腺功能参数。对大多数患者进行了自评抑郁量表（SDS）、自评焦虑量表（SAS）和艾森克人格问卷（EPQ）的评分。
这些 MDD 住院患者中，有 20.14%在过去 1 个月内有过自杀未遂。与未尝试自杀者相比，自杀未遂者的发病时间更长，低密度脂蛋白（LDL）胆固醇、总胆固醇更低，且有更多的精神病症状。然而，在 Bonferroni 校正后，所有这些显著结果均不再显著（均 P＞0.05）。Logistic 回归分析表明，自杀尝试与总胆固醇较低和更多精神病症状有关。
我们的发现支持了 MDD 患者血浆胆固醇水平低与近期自杀未遂相关的假设。
