Grana E, Zonta F, D'agostino G
Farmaco Sci. 1977 Oct;32(10):725-34.
The mechanical response of the isolated rat vas deferens to four alpha-adrenomimetic substances has been studied. The four test substances were noradrenaline, octopamine, 2-phenylethylamine and 2-(1-naphthylmethyl)imidazoline (Privin). Examination of the cumulative dose/response curves showed both qualitative and quantitative differences. Octopamine gave an alpha value (intrinsic activity) greater than that of noradrenaline; Privin proved to be a partial agonist but with affinity greater than that of noradrenaline. Various qualitative differences were also observed suggesting a possible explanation based on labilization of the membrane.
已对离体大鼠输精管对四种α-肾上腺素能物质的机械反应进行了研究。四种受试物质为去甲肾上腺素、章鱼胺、2-苯乙胺和2-(1-萘甲基)咪唑啉（Privin）。对累积剂量/反应曲线的检查显示出定性和定量的差异。章鱼胺的α值（内在活性）高于去甲肾上腺素；Privin被证明是一种部分激动剂，但其亲和力大于去甲肾上腺素。还观察到各种定性差异，这表明基于膜不稳定可能存在一种解释。
