Rong Suihar, Lin Hai, Gao Ni
Pharmaceutical Department, Guangdong Provcial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China.
Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(8):1001-3.
To investigate the rule about changes on main active compositions of Atractrylodis Macrocephalae Rhizoma before and after being processed, and to explore its processing principle.
The HPLC method was employed to determine the content of atractrylone, atractrylode I, II, III and total volatile oil of Atractrylodis Macrocephalae Rhizoma with different processes. The processing principle before and after processing of Atractrylodis Macrocephalae Rhizoma was investigated.
Compared with Atractrylodis Macrocephalae Rhizoma, the contents of atractrylone in different processed products of Atractrylodis Macrocephalae Rhizoma were decreased by some extent. The lowest content was 0.33% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt, reduced by 25.4%; the content of atractylenolide I, III were significantly increased, the highest content were 0.069% and 0.078% in Atractrylodis Macrocephalae Rhizoma of stir-fried with bran, respectively; the content of atractylenolide II was increased slightly, the highest content was 0.066% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt; the content of total volatile oil was significantly reduced, the lowest content was 0.64% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt.
The content of atractylon is significantly reduced after processing, which changed into atractrylode I, II, III by some extent, and improve the effective cure of Atractrylodis Macrocephala Rhizoma.
探讨白术炮制前后主要活性成分的变化规律，探索其炮制原理。
采用高效液相色谱法测定不同炮制方法的白术中苍术酮、苍术素Ⅰ、Ⅱ、Ⅲ及总挥发油的含量，对白术炮制前后的原理进行研究。
与白术相比，白术不同炮制品中苍术酮的含量均有不同程度降低，土炒白术中含量最低为0.33%，降低了25.4%；苍术素Ⅰ、Ⅲ含量显著增加，麸炒白术中含量最高，分别为0.069%和0.078%；苍术素Ⅱ含量略有增加，土炒白术中含量最高为0.066%；总挥发油含量显著降低，土炒白术中含量最低为0.64%。
白术炮制后苍术酮含量显著降低，部分转化为苍术素Ⅰ、Ⅱ、Ⅲ，提高了白术的疗效。
