Ukah Cornelius O, Ikpeze Okechukwu C, Eleje George U, Eke Ahizechukwu C
Health Policy and Management concentration, Masters in Public Health Program, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
J Med Case Rep. 2011 Aug 2;5:340. doi: 10.1186/1752-1947-5-340.
If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.
We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.
The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.
如果采用严格的癌诊断标准并纳入所有颗粒细胞瘤患者，那么与之相关的子宫内膜癌发病率的最佳估计值低于5%。在颗粒细胞瘤患者中，雌激素依赖型子宫内膜癌很少见，并且这些子宫内膜癌大多是高分化子宫内膜样腺癌，早期发现时预后良好。
我们报告了一例65岁绝经后伊博族尼日利亚女性的病例，该患者患有成人颗粒细胞瘤，最初被误诊为子宫内膜癌。在组织病理学确诊为卵巢高分化颗粒细胞瘤和子宫内膜核分级1级腺癌（国际妇产科联盟1B期）后，她接受了全腹子宫切除术和双侧输卵管卵巢切除术。她术后恢复良好，治疗10天后出院。
卵巢成人颗粒细胞瘤与子宫内膜癌之间的关联很少见。高度的怀疑指数以及良好的影像学和组织病理学分析对于做出这一诊断很重要。
