Mathew Anil C, Steephen Shaijin, David Renu, Ramalingam Sudha, Krishnamurthy Srikanth
Department of Community Medicine, PSG Institute of Medical Science and Research, Coimbatore, Tamil Nadu, India.
Int J Prev Med. 2011 Jul;2(3):151-7.
Studies of parental atopy, exposure to pets, and the risk of asthma have provided conflicting results. We aimed to assess the relationship between asthma among adults with parental atopy, pet keeping inside, and pet keeping outside the home. This study involved a total of 159 adults. The clinically diagnosed cases were 53 adults with asthma as per Global Initiative for Asthma (GINA) guidelines and 106 controls without asthma.
The study design was a hospital based case-control study. Information on parental atopy and exposure to pets was collected by using a self-administrated questionnaire. We used the exposure odds ratio and 95% confidence interval (CI) to quantify the relation between determinants of interest and the risk of asthma. These were estimated using logistic regression analysis with SPSS version 11.5.
The paternal and maternal history of asthma were found to have significant effect on asthma among adults with adjusted odds ratio (OR) of 6.70 (1.92-23.33 95%CI) and 3.33 (1.25-8.89 95% CI) respectively. Parental history and parental atopy significantly increased risk of asthma among adults with adjusted odds ratios of 5.78 (2.38-14.05 95% CI) and 3.65 (1.58-8.43 95% CI) respectively. There was no significant association between asthma and exposure to pets. The adjusted odds ratios for pet keeping inside and outside the house were 1.61 (0.55-4.7395%CI) and 1.32 (0.61-2.87 95%CI) respectively.
Our results support the hypothesis that both parental history and parental atopy increase the risk of asthma among adults whereas pet keeping inside and outside the house during the previous 12-month period were not significantly associated with asthma among adults.
关于父母患特应性疾病、接触宠物与哮喘风险的研究结果相互矛盾。我们旨在评估父母患特应性疾病的成年人患哮喘与在家中饲养宠物及在户外饲养宠物之间的关系。本研究共纳入159名成年人。根据全球哮喘防治创议（GINA）指南，临床诊断为哮喘的病例有53名成年人，106名对照者未患哮喘。
本研究设计为基于医院的病例对照研究。通过使用自填式问卷收集有关父母患特应性疾病及接触宠物的信息。我们使用暴露比值比和95%置信区间（CI）来量化感兴趣的决定因素与哮喘风险之间的关系。这些通过使用SPSS 11.5版进行逻辑回归分析来估计。
发现父亲和母亲的哮喘病史对成年人患哮喘有显著影响，调整后的比值比（OR）分别为6.70（1.92 - 23.33，95%CI）和3.33（1.25 - 8.89，95%CI）。父母病史和父母患特应性疾病分别使成年人患哮喘的风险显著增加，调整后的比值比分别为5.78（2.38 - 14.05，95%CI）和3.65（1.58 - 8.43，95%CI）。哮喘与接触宠物之间无显著关联。在家中及户外饲养宠物的调整后比值比分别为1.61（0.55 - 4.73，95%CI）和1.32（0.61 - 2.87，95%CI）。
我们的结果支持以下假设，即父母病史和父母患特应性疾病均会增加成年人患哮喘的风险，而在过去12个月期间在家中及户外饲养宠物与成年人患哮喘无显著关联。
